2023

• "Thioester-Based Coupled Fluorogenic Assays in Microdevice for the Detection of Single-Molecule Enzyme Activities of Esterases with Specified Substrate Recognition"  Tatsuya Ukegawa, Toru Komatsu, Mayano Minoda, Takuya Matsumoto, Takumi Iwasaka, Tadahaya Mizuno, Ryo Tachibana, Shingo Sakamoto, Kenjiro Hanaoka, Hiroyuki Kusuhara, Kazufumi Honda, Rikiya Watanabe, and Yasuteru Urano
  

  Adv. Sci.

  , 2306559 (2023). doi:10.1002/advs.202306559
• "Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5′-phosphate (PLP) via Schiff base formation"  Honami Echizen, Kenjiro Hanaoka, Kazuhito Shimamoto, Ryota Hibi, Sachiko Toma-Fukai, Hisashi Ohno, Eita Sasaki, Toru Komatsu, Tasuku Ueno, Yukihiro Tsuchiya, Yasuo Watanabe, Takao Otsuka, Hiroaki Saito, Satoru Nagatoishi, Kouhei Tsumoto, Hirotatsu Kojima, Takayoshi Okabe, Toshiyuki Shimizu and Yasuteru Urano
  

  Sci. Rep.

  , 13, 16456 (2023) doi:10.1038/s41598-023-43536-6
• "A protease activity-based machine-learning approach as a complementary tool for conventional diagnosis of diarrheapredominant irritable bowel syndrome"  Kazuki Tanaka, Naoki Tanigawa, Isaiah Song, Toru Komatsu, Yugo Kuriki, Yukari Tanaka, Shin Fukudo, Yasuteru Urano and Shinji Fukuda
  

  Front. Microbiol.

  , 14 (2023) doi:10.3389/fmicb.2023.1179534
• "Development of fluorogenic substrates for colorectal tumor-related neuropeptidases for activity-based diagnosis"  Norimichi Nagano, Yuki Ichihashi, Toru Komatsu, Hiroyuki Matsuzaki, Keisuke Hata, Toshiaki Watanabe, Yoshihiro Misawa, Misa Suzuki, Shingo Sakamoto, Yu Kagami, Ayumi Kashiro, Keiko Takeuchi, Yukihide Kanemitsu, Hiroki Ochiai, Rikiya Watanabe, Kazufumi Honda and Yasuteru Urano
  

  Chem. Sci.

  , 14, 4495-4499 (2023) doi:10.1039/D2SC07029D
  *Cover art
• "Development of pathway-oriented screening to identify compounds to control 2-methylglyoxal metabolism in tumor cells"  Kouichi Yanagi, Toru Komatsu, Yuuta Fujikawa, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Tasuku Ueno, Kenjiro Hanaoka and Yasuteru Urano
  

  Commun.Chem.

  , 6, 68 (2023) doi:10.1038/s42004-023-00864-y

2022

• "Rapid imaging of lung cancer using a red fluorescent probe to detect dipeptidyl peptidase 4 and puromycin-sensitive aminopeptidase activities"  Shun Kawashima, Daisuke Yoshida, Takafusa Yoshioka, Akira Ogasawara, Kyohhei Fujita, Masahiro Yanagiya, Masaaki Nagano, Chihiro Konoeda, Haruaki Hino, Kentaro Kitano, Masaaki Sato, Rumi Hino, Ryosuke Kojima, Toru Komatsu, Mako Kamiya, Yasuteru Urano and Jun Nakajima
  

  Sci. Rep.

  , 12, 9100- (2022) doi:10.1038/s41598-022-12665-9
• "General Design Strategy to Precisely Control the Emission of Fluorophores via a Twisted Intramolecular Charge Transfer (TICT) Process"  Kenjiro Hanaoka, Shimpei Iwaki, Kiyoshi Yagi, Takuya Myochin, Takayuki Ikeno, Hisashi Ohno, Eita Sasaki, Toru Komatsu, Tasuku Ueno, Motokazu Uchigashima, Takayasu Mikuni, Kazuki Tainaka, Shinya Tahara, Satoshi Takeuchi, Tahei Tahara, Masanobu Uchiyama, Tetsuo Nagano, and Yasuteru Urano
  

  J. Am.Chem. Soc.

  , 144, 43, 19778–19790 (2022) doi:10.1021/jacs.2c06397
• "Leading Edge Elongation by Follower Cell Interruption in Advancing Epithelial Cell Sheets"  Chika Okimura, Misaki Iwanaga, Tatsunari Sakurai, Tasuku Ueno, Yasuteru Urano, and Yoshiaki Iwadate
  

  Proc. Natl. Acad. Sci. USA.

  , 119, e2119903119- (2022) doi:10.1073/pnas.2119903119
• "Molecular Design of Near-infrared (Nir) Fluorescent Probes Targeting Exo-peptidase and Application for Detection of Dipeptidyl Peptidase 4 (DPP-4) Activity "  Yuki Hoshino, Kenjiro Hanaoka, Kei Sakamoto, Masahiro Yasunaga, Takashi Kojima, Daisuke Kotani, Ayumu Nomoto, Eita Sasaki, Toru Komatsu, Tasuku Ueno, Hiroyuki Takamaru, Yutaka Saito, Yasuyuki Seto, and Yasuteru Urano
  

  RSC chem. biol.

  , 3, 859-867 (2022) doi:10.1039/D1CB00253H
• "Development of a Fluorescent Probe Library Enabling Efficient Screening of Tumour-imaging Probes Based on Discovery of Biomarker Enzymatic Activities"  Yugo Kuriki, Takafusa Yoshioka, Mako Kamiya, Toru Komatsu, Hiroyuki Takamaru, Kyohhei Fujita, Hirohisa Iwaki, Aika Nanjo, Yuki Akagi, Kohei Takeshita, Haruaki Hino, Rumi Hino, Ryosuke Kojima, Tasuku Ueno, Kenjiro Hanaoka, Seiichiro Abe,Yutaka Saito, Jun Nakajima, and Yasuteru Urano
  

  Chem. Sci.

  , 13, 4474-4481 (2022) doi:10.1039/d1sc06889j
  *Cover art
• "Rapid Visualization of Deeply Located Tumors In Vivo by Intravenous Administration of a γ-Glutamyltranspeptidase-Activated Fluorescent Probe"  Akihiro Nakada, Takuma Maruyama, Mako Kamiya, Kenjiro Hanaoka, and Yasuteru Urano
  

  Bioconjug. Chem.

  , 33, 3, 523–529 (2022) doi:10.1021/acs.bioconjchem.2c00039
• "Molecular probes for fluorescence image-guided cancer surgery"  Ren Ito, Mako Kamiya, Yasuteru Urano
  

  Current Opinion in Chemical Biology

  , 67, 102112 (2021) doi:10.1016/j.cbpa.2021.102112

2021

• "Discovery of an F-actin–Binding Small Molecule Serving as a Fluorescent Probe and a Scaffold for Functional Probes"  Takeru Takagi, Tasuku Ueno, Keisuke Ikawa, Daisuke Asanuma, Yusuke Nomura, Shin-nosuke Uno, Toru Komatsu, Mako Kamiya, Kenjiro Hanaoka, Chika Okimura, Yoshiaki Iwadate, Kenzo Hirose, Tetsuo Nagano, Kaoru Sugimura and Yasuteru Urano
  

  Sci. Adv.

  , 7, eabg8585- (2021) doi:10.1126/sciadv.abg8585
• "Establishment of live-cell-based coupled assay system for identification of compounds to modulate metabolic activities of cells"  Kouichi Yanagi, Toru Komatsu, Tasuku Ueno, Kenjiro Hanaoka, Yasuteru Urano
  

  Cell Reports.

  , 36(1), 109311 (2021) doi:10.1016/j.celrep.2021.109311
• "Nongenetic Control of Receptor Signaling Dynamics with a DNA-Based Optochemical Tool "  Ryosuke Ueki, Shota Hayashi, Masaya Tsunoda, Momoko Akiyama, Hanrui Liu, Tasuku Ueno, Yasuteru Urano and Shinsuke Sando
  

  Chem. Commun.

  , In press doi:10.1039/D1CC01968F
• "MITOL promotes cell survival by degrading Parkin during mitophagy"  Isshin Shiiba, Keisuke Takeda, Shun Nagashima, Naoki Ito, Takeshi Tokuyama, Shun‐Ichi Yamashita, Tomotake Kanki, Toru Komatsu, Yasuteru Urano, Yuuta Fujikawa, Ryoko Inatome, and Shigeru Yanagi
  

  EMBO Rep.

  , 2021, e49097 (2021) doi:10.15252/embr.201949097

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2020

• "Amino BODIPY-Based Blue Fluorescent Probes for Aldehyde Dehydrogenase 1 Expressing Cells"  Atsushi Yagishita, Tasuku Ueno, Katsuya Tsuchihara, and Yasuteru Urano
  

  Bioconjugate Chem.

  , In press doi:10.1021/acs.bioconjchem.0c00565
• "Design, synthesis and evaluation of enzyme-responsive fluorogenic probes based on pyridine-flanked diketopyrrolopyrrole dyes"  Sebastien Jenni, Flavien Ponsot, Pierre Baroux, Lucile Collard, Takayuki Ikeno, Kenjiro Hanaoka, Valentin Quesneau, Kevin Renault and Anthony Romieu
  

  Spectrochim. Acta A Mol. Biomol. Spectrosc.

  , In press doi:10.1016/j.saa.2020.119179
• "Calciprotein particle-induced cytotoxicity via lysosomal dysfunction and altered cholesterol distribution in renal epithelial HK-2 cells"  Rina Kunishige, Mai Mizoguchi, Asako Tsubouchi, Kenjiro Hanaoka, Yutaka Miura, Hiroshi Kurosu, Yasuteru Urano, Makoto Kuro-o and Masayuki Murata
  

  Sci. Rep.

  , 10, 20125 (2020) doi:10.1038/s41598-020-77308-3
• "Recent Advances in Probe Design to Detect Reactive Sulfur Species and in the Chemical Reactions Employed for Fluorescence Switching"  Honami Echizen and Kenjiro Hanaoka
  

  J. Clin. Biochem. Nutr.

  , In press doi:10.3164/jcbn.20-18
• "How Viscous is the Solid-like Structure at the Interface of Ionic Liquids? A Study Using Total Internal Reflection Fluorescence Spectroscopy with a Fluorescent Molecular Probe Sensitive to High Viscosity"  Naoya Nishi, Takashi Yamazawa, Tetsuo Sakka, Hiroki Hotta,Takayuki Ikeno, Kenjiro Hanaoka and Hiromi Takahashi
  

  Langmuir

  , 36, 10397-10403 (2020) doi:10.1021/acs.langmuir.0c01528
• "A cytosolically localized far-red to near-infrared rhodamine-based fluorescent probe for calcium ions"  Koji Numasawa, Kenjiro Hanaoka, Takayuki Ikeno, Honami Echizen, Tomoe Ishikawa, Masakazu Morimoto, Toru Komatsu, Tasuku Ueno, Yuji Ikegaya, Tetsuo Nagano and Yasuteru Urano
  

  Analyst

  , 145, 7736-7740 doi:10.1039/D0AN01739F
• "Antibody Clicking as a Strategy to Modify Antibody Functionalities on the Surface of Targeted Cells"  Toru Komatsu, Etsu Kyo, Haruki Ishii, Kyoji Tsuchikama, Aiko Yamaguchi, Tasuku Ueno, Kenjiro Hanaoka, and Yasuteru Urano
  

  J. Am. Chem. Soc.

  , 142, 15644-15648 doi:10.1021/jacs.0c05331
• "Covalent Self-labeling of Tagged Proteins with Chemical Fluorescent Dyes in BY_-2 Cells and Arabidopsis Seedlings"  Ryu Iwatate, Akira Yoshinari, Noriyoshi Yagi, Marek Grzybowski, Hiroaki Ogasawara, Mako Kamiya, Toru Komatsu, Masayasu Taki, Shieghiro Yamaguschi, Wolf B. Frommer, Masayoshi Nakamura
  

  Plant Cell

  , 32, 3081-3094 doi:10.1105/tpc.20.00439
• "Real-time in vivo Imaging of Extracellular ATP in the Brain with a Hybrid-type Fluorescent Sensor"  Nami Kitajima, Kenji Takikawa, Hiroshi Sekiya, Kaname Satoh, Daisuke Asanuma, Hirokazu Sakamoto, Shodai Takahashi, Kenjiro Hanaoka, Yasuteru Urano, Shigeyuki Namiki, Masamitsu Iino, Kenzo Hirose
  

  eLife

  , In press doi:10.7554/eLife.57544
• "Multiplexed single-molecule enzyme activity analysis for counting disease-related proteins in biological samples"  Shingo Sakamoto, Toru Komatsu, Rikiya Watanabe, Yi Zhang, Taiki Inoue, Mitsuyasu Kawaguchi, Hidehiko Nakagawa, Takaaki Ueno, Takuji Okusaka, Kazufumi Honda, Hiroyuki Noji, and Yasuteru Urano
  

  Sci. Adv.

  , 6, no. 11, eaay0888 (2020) doi:10.1126/sciadv.aay0888
• "A Fluorescent Probe for Rapid, High-Contrast Visualization of Folate-Receptor-Expressing Tumors in Vivo"  Koji Numasawa, Kenjiro Hanaoka, Naoko Saito, Yoshifumi Yamaguchi, Takayuki Ikeno, Honami Echize, Masahiro Yasunaga, Toru Komatsu, Tasuku Ueno, Masayuki Miura, Tetsuo Nagano and Yasuteru Urano
  

  Angew. Chem. Int. Ed.

  , 59, 6015-6020 (2020) doi:10.1002/anie.201914826
• "Hypoxia-inducible factor-1 alpha maintains mouse articular cartilage through suppression of NF-κB signaling"  Keita okada, Daisuke Mori, Yuma Makii, Hideki Nakamoto, Yasutaka Murahashi, Fumiko Yano, Song Ho Chang, Yuki Taniguchi, Hiroshi Kobayashi, Hiroaki Semba, Norihiko Takeda, Wen Piao, Kenjiro Hanaoka, Tetsuo Nagano, Sakae Tanaka, and Taku Saito
  

  Sci. Rep.

  , 10, Article number: 5425 (2020) doi:10.1038/s41598-020-62463-4
• "Rational Design of A Near-infrared Fluorescence Probe for Ca²⁺ Based on Phosphorus-substituted Rhodamines Utilizing Photoinduced Electron Transfer"  Shodai Takahashi, Kenjiro Hanaoka, Yohei Okubo, Honami Echizen, Takayuki Ikeno, Toru Komatsu, Tasuku Ueno, Kenzo Hirose, Masamitsu Iino, Tetsuo Nagano and Yasuteru Urano
  

  Chem. Asian J.

  , 15, 524-530 (2020) doi:10.1002/asia.201901689
• "Metabolic Pathway-oriented Screening Targeting S-Adenosyl-L-methionine Reveals the Epigenetic Remodeling Activities of Naturally Occurring Catechols"  Shusuke Ogihara, Toru Komatsu, Yukihiro Itoh, Yuka Miyake,Takayoshi Suzuki, Kouichi Yanagi, Yusuke Kimura, Tasuku Ueno, Kenjiro Hanaoka, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, and Yasuteru Urano
  

  J. Am. Chem. Soc.

  , 142, 21-26 (2020) doi:10.1021/jacs.9b08698

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2019

• "Development of Ratiometric Carbohydrate Sensor Based on Boron Dipyrromethene (BODIPY) Scaffold"  Nusaiba Madappuram Cheruthu, Toru Komatsu, Tasuku Ueno, Kenjiro Hanaoka and Yasuteru Urano
  

  Bioorg. Med. Chem. Lett.

  , 29, 126684 (2019) doi:10.1016/j.bmcl.2019.126684
• "Separation-Based Enzymomics Assay for the Discovery of Altered Peptide-Metabolizing Enzymatic Activities in Biosamples"  Yuki Ichihashi, Toru Komatsu, Etsu Kyo, Hiroyuki Matsuzaki, Keisuke Hata, Toshiaki Watanabe, Tasuku Ueno, Kenjiro Hanaoka, and Yasuteru Urano
  

  Anal. Chem.

  , 91, 11497-11501 (2019) doi:10.1021/acs.analchem.9b03016
• "Design strategy for germanium-rhodamine based pH-activatable near-infrared fluorescence probes suitable for biological applications"  Yuichiro Koide, Ryosuke Kojima, Kenjiro Hanaoka, Koji Numasawa, Toru Komatsu, Tetsuo Nagano, Hisataka Kobayashi, Yasuteru Urano
  

  Commun. Chem.

  , 2, Article number: 94 (2019) doi:10.1038/s42004-019-0194-4
• "Chemical Toolbox for "Live" Biochemistry to Understand Enzymatic Functions in Living Systems"  Toru Komatsu, and Yasuteru Urano
  

  J. Biochem.

  , in press doi:10.1093/jb/mvz074
• "Development of Ratiometric Carbohydrate Sensor Based on Boron Dipyrromethene (BODIPY) Scaffold"  Nusaiba Madappuram Cheruthu, Toru Komatsu, Tasuku Ueno, Kenjiro Hanaoka and Yasuteru Urano
  

  Bioorg. Med. Chem. Lett.

  , In press doi:10.1016/j.bmcl.2019.126684
• "Separation-Based Enzymomics Assay for the Discovery of Altered Peptide-Metabolizing Enzymatic Activities in Biosamples"  Yuki Ichihashi, Toru Komatsu, Etsu Kyo, Hiroyuki Matsuzaki, Keisuke Hata, Toshiaki Watanabe, Tasuku Ueno, Kenjiro Hanaoka, and Yasuteru Urano
  

  Anal. Chem.

  , 91, 11497-11501 (2019) doi:10.1021/acs.analchem.9b03016
• "Design strategy for germanium-rhodamine based pH-activatable near-infrared fluorescence probes suitable for biological applications"  Yuichiro Koide, Ryosuke Kojima, Kenjiro Hanaoka, Koji Numasawa, Toru Komatsu, Tetsuo Nagano, Hisataka Kobayashi, Yasuteru Urano
  

  Commun. Chem.

  , 2, Article number: 94 (2019) doi:10.1038/s42004-019-0194-4
• "Design and Synthesis of an Activatable Photoacoustic Probe for Hypochlorous Acid"  Takayuki Ikeno, Kenjiro Hanaoka, Shimpei Iwaki, Takuya Myochin, Yoshiaki　Murayama, Hisashi Ohde, Toru Komatsu, Tasuku Ueno, Tetsuo Nagano, Yasuteru Urano
  

  Anal. Chem.

  , 91, 9086-9092 (2019) doi:10.1021/acs.analchem.9b01529
• "Design of Photostable, Activatable Near‐Infrared Photoacoustic Probes Using Tautomeric Benziphthalocyanine as a Platform"  Naoyuki Toriumi, Norihito Asano, Takayuki Ikeno, Atsuya Muranaka, Kenjiro Hanaoka, Yasuteru Urano, Masanobu Uchiyama
  

  Angew. Chem. Int. Ed.

  , 58, 7788-7791 (2019) doi:10.1002/anie.201903303
• "A Red Fluorescence Probe Targeted to Dipeptidylpeptidase-IV for Highly Sensitive Detection of Esophageal Cancer" Akira Ogasawar, Mako Kamiya, Kei Sakamoto, Yugo Kuriki, Kyohhei Fujita, Toru Komatsu, Tasuku Ueno, Kenjiro Hanaoka, Haruna Onoyama, Hiroyuki Abe, Yosuke Tsuji, Mitsuhiro Fujishiro, Kazuhiko Koike, Masahi Fukayama Yasuyuki Seto and Yasuteru Urano
  

  Bioconjugate chem.

  , 30, 1055-1060 (2019) doi:10.1021/acs.bioconjchem.9b00198
• "Development of a Platform for Activatable Fluorescent Substrates of Glucose Transporters (GLUTs)"  Tomohiro Takasugi, Kenjiro Hanaoka, Ayako Sasaki, Takayuki Ikeno, Toru Komatsu, Tasuku Ueno, Katsuya Yamada, Yasuteru Urano
  

  Bioorg. Med. Chem.

  , 27, 2122-2126 (2019) doi:10.1016/j.bmc.2019.02.055
• "Development and Validation of An Improved Diced Electrophoresis Gel Assay Cutter-Plate System for Enzymomics Studies"  Toru Komatsu, Masahiro Shimoda, Yukiko Kawamura, Yasuteru Urano, TetsuoNagano
  

  Biochim. Biophys. Acta

  , 1867, 82-87 (2019) doi:10.1016/j.bbapap.2018.06.004
• "Development of Novel Dark Quenchers and Their Application to Imaging Probes"  Kenjiro Hanaoka
  

  YAKUGAKU ZASSHI

  , 139, 277-283 (2019) doi:10.1248/yakushi.18-00174-3

Page Top

2018

• "Rapid Detection of Metastatic Lymph Nodes of Colorectal Cancer with A Gamma-Glutamyl Transpeptidase-Activatable Fluorescence Probe."  Hidemasa Kubo, Kenjiro Hanaoka, Yugo Kuriki, Toru Komatsu, Tasuku Ueno, Ryosuke Kojima, Mako Kamiya, Yasutoshi Murayama, Eigo Otsuji and Yasuteru Urano.
  

  Sci. Rep.

  , 8, Article number: 17781-6942 (2018) doi:10.1038/s41598-018-36062-3
• "Red-Shifted Fluorogenic Substrate for Detecting Lacz‐Positive Cells in Living Tissue with Single‐Cell Resolution"  Hiroki Ito, Yu Kawamata, Mako Kamiya, Kayoko Tsuda-Sakurai, Shinji Tanaka, Tasuku Ueno Toru Komatsu, Kenjiro Hanaoka, Shigeo Okabe, Masayuki Miura and Yasuteru Urano
  

  Angew. Chem. Int. Ed.

  , 57, 15702-15706 (2018) doi:10.1002/anie.201808670
• "High-Throughput Single-Molecule Bioassay Using Micro-Reactor Arrays with A Concentration Gradient of Target Molecules"  Rikiya Watanabe, Toru Komatsu, Shingo Sakamoto, Yasuteru Urano, and Hiroyuki Noji
  

  Lab Chip

  , 19, 2849-2853 (2018) doi:10.1039/C8LC00535D
• "Synthesis of Unsymmetrical Si-Rhodamine Fluorophores and Application to A Far-Red to Near-Infrared Fluorescence Probe for Hypoxia"  Kenjiro Hanaoka, Yu Kagami, Wen Piao, Takuya Myochin, Koji Numasawa, Yugo Kuriki, Takayuki Ikeno, Tasuku Ueno, Toru Komatsu, Takuya Terai, Tetsuo Nagano and Yasuteru Urano
  

  Chem. Commun.

  , 54, 6939-6942 (2018) doi:10.1039/c8cc02451k
• "Development of a Series of Practical Fluorescent Chemical Tools To Measure pH Values in Living Samples"  Shodai Takahashi, Yu Kagami, Kenjiro Hanaoka, Takuya Terai, Toru Komatsu, Tasuku Ueno, Masanobu Uchiyama, Ikuko Koyama-Honda, Noboru Mizushima, Tomohiko Taguchi, Hiroyuki Arai, Tetsuo Nagano, and Yasuteru Urano
  

  J. Am. Chem. Soc.

  , 140, 5925-5933 (2018) doi:10.1021/jacs.8b00277
• "N-Acetyl Cysteine Functions as a Fast-Acting Antioxidant by Triggering Intracellular H₂S and Sulfane Sulfur Production"  Daria Ezerin‚ Yoko Takano, Kenjiro Hanaoka, Yasuteru Urano and Tobias P. Dick
  

  Cell Chem. Biol.

  , 25, 447-459.e4 (2018) doi:10.1016/j.chembiol.2018.01.011
• "A Protein-Coupled Fluorescent Probe For Organelle-Specific Imaging of Na⁺ "  Ryo Taguchi, Takuya Terai, Tasuku Ueno, Toru Komatsu, Kenjiro Hanaoka, Yasuteru Urano
  

  Sens. Act. B: Chem.

  , 265, 575-581 (2018) doi:10.1016/j.snb.2018.03.090
• "Establishment of Molecular Design Strategy To Obtain Activatable Fluorescent Probes for Carboxypeptidases" Yugo Kuriki, Mako Kamiya, Hidemasa Kubo, Toru Komatsu, Tasuku Ueno, Ryo Tachibana, Kento Hayashi, Kenjiro Hanaoka, Suguru Yamashita, Takeaki Ishizawa, Norihiro Kokudo, and Yasuteru Urano
  

  J. Am. Chem. Soc.

  , 140, 1767-1773 (2018) doi:10.1021/jacs.7b11014

Page Top

2017年

• "An Activatable Photosensitizer Targeted to γ-Glutamyltranspeptidase"  Mayumi Chiba, Yuki Ichikawa, Mako Kamiya, Toru Komatsu, Tasuku Ueno, Kenjiro Hanaoka, Tetsuo Nagano, Norbert Lange and Yasuteru Urano
  

  Angew. Chem. Int. Ed.

  , 56, 10418-10422 (2017)  doi:10.1002/anie.201704793
• "Molecular imaging of aberrant crypt foci in the human colon targeting glutathione S-transferase P1-1" Naoki Muguruma, Koichi Okamoto, Tadahiko Nakagawa, Katsutaka Sannomiya, Shota Fujimoto, Yasuhiro Mitsui, Tetsuo Kimura, Hiroshi Miyamoto, Jun Higashijima, Mitsuo Shimada, Yoko Horino, Shinya Matsumoto, Kenjiro Hanaoka, Tetsuo Nagano, Makoto Shibutani and Tetsuji Takayama
  

  Sci. Rep.

  , 7, Article number: 6536 (2017) doi:10.1038/s41598-017-06857-x
• "Development of an Azo-based Photosensitizer Activated under Mild Hypoxia for Photodynamic Therapy" Wen Piao, Kenjiro Hanaoka, Tomotsumi Fujisawa, Satoshi Takeuchi, Toru Komatsu, Tasuku Ueno, Takuya Terai, Tahei Tahara, Tetsuo Nagano and Yasuteru Urano
  

  J. Am. Chem. Soc.

  , 139, 13713–13719 (2017)   doi:10.1021/jacs.7b05019
• "Potential of Enzymomics Methodologies to Characterize Disease-Related Protein Functions" Toru Komatsu
  

  Chem.Pharm.Bull.,

  65, 605-610 (2017)  doi:10.1248/cpb.c17-00144
• "Hydrogen Sulfide Donor Micelles Protect Cardiomyocytes from Ischemic Cell Death" Tomoka Takatani-Nakase, Miku Katayama, Chihiro Matsui, Kenjiro Hanaoka, André J. van der Vlies, Koichi Takahashi, Ikuhiko Nakase and Urara Hasegawa
  

  Mol. Biosys.

  , 13, 1705-1708 (2017)  doi:10.1039/C7MB00191F
• "Polysulfides (H₂S_n) Produced from the Interaction of Hydrogen Sulfide (H₂S) and Nitric Oxide (NO) Activate TRPA1 Channels" Ryo Miyamoto, Shin Koike, Yoko Takano, Norihiro Shibuya, Yuka Kimura, Kenjiro Hanaoka, Yasuteru Urano, Yuki Ogasawara and Hideo Kimura
  

  Sci. Rep.

  , 7 Article number: 45995 (2017) doi:10.1038/srep45995
• "Fluorescent Probes and Selective Inhibitors for Biological Studies of Hydrogen Sulfide- and Polysulfide-Mediated Signaling" Yoko Takano, Honami Echizen and Kenjiro Hanaoka Abstract
  

  Antioxid. Redox Signal.

  , 27, 669-683 (2017)  doi:10.1089/ars.2017.7070
• "Fluorescence Detection of Serum Albumin with a Turnover-based Sensor Utilizing Kemp Elimination"  Shingo Sakamoto, Toru Komatsu, Tasuku Ueno, Kenjiro Hanaoka and Yasuteru Urano
  

  Bioorg. Med. Chem. Lett.,

    27, 3464-3467 (2017)  doi:10.1016/j.bmcl.2017.05.076
• "Meeting Proceedings ICBS2016 - Translating the Power of Chemical Biology to Clinical Advances"  Yugo Kuriki, Toru Komatsu, Peter D. Ycas, Sara K. Coulup, Erick J. Carlson, and William C. K. Pomerantz
  

  ACS Chem. Biol.,

  12, 869–877 (2017) doi:10.1021/acschembio.7b00205
• "Synthesis of Practical Red Fluorescent Probe for Cytoplasmic Calcium Ions with Greatly Improved Cell-membrane Permeability" Kazuhisa Hirabayashi, Kenjiro Hanaoka, Takahiro Egawa, Chiaki Kobayashi, Shodai Takahashi, Toru Komatsu, Tasuku Ueno, Takuya Terai, Yuji Ikegaya and Tetsuo Nagano
  

  Data in Brief

  , 12, 351-357 (2017) doi:10.1016/j.dib.2017.04.011
• "Silicon-substituted Xanthene Dyes and their Unique Photophysical Properties for Fluorescent probes" Takayuki Ikeno, Tetsuo Nagano, Kenjiro Hanaoka
  

  Chem. Asian

  , 12, 1435–1446 (2017) doi:10.1002/asia.201700385
• "Discovery of Cell-type-specific and Disease-related Enzymatic Activity Changes via Global Evaluation of Peptide Metabolism" Jun Onagi, Toru Komatsu, Yuki Ichihashi, Yugo Kuriki, Mako Kamiya, Takuya Terai, Tasuku Ueno, Kenjiro Hanaoka, Hiroyuki Matsuzaki, Keisuke Hata, Toshiaki Watanabe, Tetsuo Nagano, and Yasuteru Urano
  

  J. Am. Chem. Soc.,

  139, 3465–3472 (2017)  doi:10.1021/jacs.6b11376
• "Enzyme-Loaded Polyion Complex Vesicles as in Vivo Nanoreactors Working Sustainably under the Blood Circulation: Characterization and Functional Evaluation"  Daiki Sueyoshi, Yasutaka Anraku, Toru Komatsu, Yasuteru Urano and Kazunori Kataoka
  

  Biomacromolecules,

  18, 1189–1196 (2017)  doi:10.1021/acs.biomac.6b01870
• "Development of an Azoreductase-based Reporter System with Synthetic Fluorogenic Substrates"  Narae Shin, Kenjiro Hanaoka, Wen Piao, Takuya Miyakawa, Tomotsumi Fujisawa, Satoshi Takeuchi, Shodai Takahashi, Toru Komatsu, Tasuku Ueno, Takuya Terai, Tahei Tahara, Masaru Tanokura, Tetsuo Nagano and Yasuteru Urano
  

  ACS Chem. Biol.,

  12, 558–563 (2017)  doi:10.1021/acschembio.6b00852
• "Development of Highly Selective Fluorescent Probe Enabling Flow-Cytometric Isolation of ALDH3A1-Positive Viable Cells" Atsushi Yagishita, Tasuku Ueno, Hiroyasu Esumi, Hideyuki Saya, Kazuhiro Kaneko, Katsuya Tsuchihara and Yasuteru Urano
  

  Bioconjugate Chem.,

  28, 302–306 (2017)  doi:10.1021/acs.bioconjchem.6b00618
• "Improving The Solubility of Artificial Ligands of Streptavidin to Enable More Practical Reversible Switching of Protein Localization in Cells" Ryo Tachibana, Takuya Terai, Gaelle Boncompain, Shigeru Sugiyama, Nae Saito, Franck Perez and Yasuteru Urano
  

  ChemBioChem

  18, 358–362 (2017) doi:10.1002/cbic.201600640
• "Development of a Reversible Fluorescent Probe for Reactive Sulfur Species, Sulfane Sulfur, and its Biological Application" Yoko Takano, Kenjiro Hanaoka, Kazuhito Shimamoto, Ryo Miyamoto, Toru Komatsu, Tasuku Ueno, Takuya Terai, Hideo Kimura, Tetsuo Nagano and Yasuteru Urano
  

  Chem Commun.,

  53, 1064-1067 (2017)  doi:10.1039/C6CC08372B
• "Discovery and Mechanistic Characterization of Selective Inhibitors of H₂S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide" Kenjiro Hanaoka, Kiyoshi Sasakura, Yusuke Suwanai, Sachiko Toma-Fukai, Kazuhito Shimamoto, Yoko Takano, Norihiro Shibuya, Takuya Terai, Toru Komatsu, Tasuku Ueno, Yuki Ogasawara, Yukihiro Tsuchiya, Yasuo Watanabe, Hideo Kimura, Chao Wang, Masanobu Uchiyama, Hirotatsu Kojima, Takayoshi Okabe, Yasuteru Urano, Toshiyuki Shimizu and Tetsuo Nagano
  

  Sci. Reports

  7, Article number: 40227 (2017)   doi:10.1038/srep40227
• "Development of Chemical Tools to Monitor and Control Isoaspartyl Peptide Methyltransferase Activity" Yusuke Kimura, Toru Komatsu, Kouichi Yanagi, Kenjiro Hanaoka, Tasuku Ueno, Takuya Terai, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, and Yasuteru Urano
  

  Angew. Chem. Int. Ed.,

  56, 153–157 (2017) doi:10.1002/anie.201608677

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2017年

• "Molecular imaging of aberrant crypt foci in the human colon targeting glutathione S-transferase P1-1" Naoki Muguruma, Koichi Okamoto, Tadahiko Nakagawa, Katsutaka Sannomiya, Shota Fujimoto, Yasuhiro Mitsui, Tetsuo Kimura, Hiroshi Miyamoto, Jun Higashijima, Mitsuo Shimada, Yoko Horino, Shinya Matsumoto, Kenjiro Hanaoka, Tetsuo Nagano, Makoto Shibutani and Tetsuji Takayama
  

  Sci. Rep.

  , 7, Article number: 6536 (2017) doi:10.1038/s41598-017-06857-x
• "Development of an Azo-based Photosensitizer Activated under Mild Hypoxia for Photodynamic Therapy" Wen Piao, Kenjiro Hanaoka, Tomotsumi Fujisawa, Satoshi Takeuchi, Toru Komatsu, Tasuku Ueno, Takuya Terai, Tahei Tahara, Tetsuo Nagano and Yasuteru Urano
  

  J. Am. Chem. Soc.

  , 139, 13713–13719 (2017)   doi:10.1021/jacs.7b05019
• "Potential of Enzymomics Methodologies to Characterize Disease-Related Protein Functions" Toru Komatsu
  

  Chem.Pharm.Bull.,

  65, 605-610 (2017)  doi:10.1248/cpb.c17-00144
• "Hydrogen Sulfide Donor Micelles Protect Cardiomyocytes from Ischemic Cell Death" Tomoka Takatani-Nakase, Miku Katayama, Chihiro Matsui, Kenjiro Hanaoka, André J. van der Vlies, Koichi Takahashi, Ikuhiko Nakase and Urara Hasegawa
  

  Mol. Biosys.

  , 13, 1705-1708 (2017)  doi:10.1039/C7MB00191F
• "Polysulfides (H₂S_n) Produced from the Interaction of Hydrogen Sulfide (H₂S) and Nitric Oxide (NO) Activate TRPA1 Channels" Ryo Miyamoto, Shin Koike, Yoko Takano, Norihiro Shibuya, Yuka Kimura, Kenjiro Hanaoka, Yasuteru Urano, Yuki Ogasawara and Hideo Kimura
  

  Sci. Rep.

  , 7 Article number: 45995 (2017) doi:10.1038/srep45995
• "Fluorescent Probes and Selective Inhibitors for Biological Studies of Hydrogen Sulfide- and Polysulfide-Mediated Signaling" Yoko Takano, Honami Echizen and Kenjiro Hanaoka Abstract
  

  Antioxid. Redox Signal.

  , 27, 669-683 (2017)  doi:10.1089/ars.2017.7070
• "Fluorescence Detection of Serum Albumin with a Turnover-based Sensor Utilizing Kemp Elimination"  Shingo Sakamoto, Toru Komatsu, Tasuku Ueno, Kenjiro Hanaoka and Yasuteru Urano
  

  Bioorg. Med. Chem. Lett.,

    27, 3464-3467 (2017)  doi:10.1016/j.bmcl.2017.05.076
• "Meeting Proceedings ICBS2016 - Translating the Power of Chemical Biology to Clinical Advances"  Yugo Kuriki, Toru Komatsu, Peter D. Ycas, Sara K. Coulup, Erick J. Carlson, and William C. K. Pomerantz
  

  ACS Chem. Biol.,

  12, 869–877 (2017) doi:10.1021/acschembio.7b00205
• "Synthesis of Practical Red Fluorescent Probe for Cytoplasmic Calcium Ions with Greatly Improved Cell-membrane Permeability" Kazuhisa Hirabayashi, Kenjiro Hanaoka, Takahiro Egawa, Chiaki Kobayashi, Shodai Takahashi, Toru Komatsu, Tasuku Ueno, Takuya Terai, Yuji Ikegaya and Tetsuo Nagano
  

  Data in Brief

  , 12, 351-357 (2017) doi:10.1016/j.dib.2017.04.011
• "Silicon-substituted Xanthene Dyes and their Unique Photophysical Properties for Fluorescent probes" Takayuki Ikeno, Tetsuo Nagano, Kenjiro Hanaoka
  

  Chem. Asian

  , 12, 1435–1446 (2017) doi:10.1002/asia.201700385
• "Discovery of Cell-type-specific and Disease-related Enzymatic Activity Changes via Global Evaluation of Peptide Metabolism" Jun Onagi, Toru Komatsu, Yuki Ichihashi, Yugo Kuriki, Mako Kamiya, Takuya Terai, Tasuku Ueno, Kenjiro Hanaoka, Hiroyuki Matsuzaki, Keisuke Hata, Toshiaki Watanabe, Tetsuo Nagano, and Yasuteru Urano
  

  J. Am. Chem. Soc.,

  139, 3465–3472 (2017)  doi:10.1021/jacs.6b11376
• "Enzyme-Loaded Polyion Complex Vesicles as in Vivo Nanoreactors Working Sustainably under the Blood Circulation: Characterization and Functional Evaluation"  Daiki Sueyoshi, Yasutaka Anraku, Toru Komatsu, Yasuteru Urano and Kazunori Kataoka
  

  Biomacromolecules,

  18, 1189–1196 (2017)  doi:10.1021/acs.biomac.6b01870
• "Development of an Azoreductase-based Reporter System with Synthetic Fluorogenic Substrates"  Narae Shin, Kenjiro Hanaoka, Wen Piao, Takuya Miyakawa, Tomotsumi Fujisawa, Satoshi Takeuchi, Shodai Takahashi, Toru Komatsu, Tasuku Ueno, Takuya Terai, Tahei Tahara, Masaru Tanokura, Tetsuo Nagano and Yasuteru Urano
  

  ACS Chem. Biol.,

  12, 558–563 (2017)  doi:10.1021/acschembio.6b00852
• "Development of Highly Selective Fluorescent Probe Enabling Flow-Cytometric Isolation of ALDH3A1-Positive Viable Cells" Atsushi Yagishita, Tasuku Ueno, Hiroyasu Esumi, Hideyuki Saya, Kazuhiro Kaneko, Katsuya Tsuchihara and Yasuteru Urano
  

  Bioconjugate Chem.,

  28, 302–306 (2017)  doi:10.1021/acs.bioconjchem.6b00618
• "Improving The Solubility of Artificial Ligands of Streptavidin to Enable More Practical Reversible Switching of Protein Localization in Cells" Ryo Tachibana, Takuya Terai, Gaelle Boncompain, Shigeru Sugiyama, Nae Saito, Franck Perez and Yasuteru Urano
  

  ChemBioChem

  18, 358–362 (2017) doi:10.1002/cbic.201600640
• "Development of a Reversible Fluorescent Probe for Reactive Sulfur Species, Sulfane Sulfur, and its Biological Application" Yoko Takano, Kenjiro Hanaoka, Kazuhito Shimamoto, Ryo Miyamoto, Toru Komatsu, Tasuku Ueno, Takuya Terai, Hideo Kimura, Tetsuo Nagano and Yasuteru Urano
  

  Chem Commun.,

  53, 1064-1067 (2017)  doi:10.1039/C6CC08372B
• "Discovery and Mechanistic Characterization of Selective Inhibitors of H₂S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide" Kenjiro Hanaoka, Kiyoshi Sasakura, Yusuke Suwanai, Sachiko Toma-Fukai, Kazuhito Shimamoto, Yoko Takano, Norihiro Shibuya, Takuya Terai, Toru Komatsu, Tasuku Ueno, Yuki Ogasawara, Yukihiro Tsuchiya, Yasuo Watanabe, Hideo Kimura, Chao Wang, Masanobu Uchiyama, Hirotatsu Kojima, Takayoshi Okabe, Yasuteru Urano, Toshiyuki Shimizu and Tetsuo Nagano
  

  Sci. Reports

  7, Article number: 40227 (2017)   doi:10.1038/srep40227
• "Development of Chemical Tools to Monitor and Control Isoaspartyl Peptide Methyltransferase Activity" Yusuke Kimura, Toru Komatsu, Kouichi Yanagi, Kenjiro Hanaoka, Tasuku Ueno, Takuya Terai, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, and Yasuteru Urano
  

  Angew. Chem. Int. Ed.,

  56, 153–157 (2017) doi:10.1002/anie.201608677

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2016年

• "Identification of Lung Inflammation-Related Elevation of Acylamino Acid Releasing Enzyme (APEH) Activity Using an Enzymomics Approach" Toru Komatsu, Kentaro Yoshioka, Kenjiro Hanaoka, Takuya Terai Tasuku Ueno, Tetsuo Nagano and Yasuteru Urano
  

  Chem. Pharm. Bull.

  , 11, 1533-1538 (2016) doi:10.1248/cpb.c16-00540
• "A Single Fluorescent Probe to Visualize Hydrogen Sulfide and Hydrogen Polysulfides with Different Fluorescence Signals" Wei Chen, Armando Pacheco, Yoko Takano, Jacob J. Day, Kenjiro Hanaoka and Ming Xian
  

  Angew. Chem. Int. Ed.

  , 55, 9993-9996 (2016) doi:10.1002/anie.201604892
• "Rapid and sensitive detection of early esophageal squamous cell carcinoma with fluorescence probe targeting dipeptidylpeptidase IV" Haruna Onoyama, Mako Kamiya, Yugo Kuriki, Toru Komatsu, Hiroyuki Abe, Yosuke Tsuji, Koichi Yagi, Yukinori Yamagata, Susumu Aikou, Masato Nishida, Kazuhiko Mori, Hiroharu Yamashita, Mitsuhiro Fujishiro, Sachiyo Nomura, Nobuyuki Shimizu, Masashi Fukayama, Kazuhiko Koike, Yasuteru Urano and Yasuyuki Seto
  

  Sci. Rep.,

  6, 26399 (2016) doi:10.1038/srep26399
• "Development of Practical Red Fluorescent Probe for Cytoplasmic Calcium Ions with Greatly Improved Cell-membrane Permeability"  Kazuhisa Hirabayashi, Kenjiro Hanaoka, Takahiro Egawa, Chiaki Kobayashi, Shodai Takahashi, Toru Komatsua, Tasuku Ueno, Takuya Terai, Yuji Ikegaya, Tetsuo Nagano, and Yasuteru Urano
  

  Cell Calcium

  60, 256–265 (2016). doi:10.1016/j.ceca.2016.06.002
• "Unexpected photo-instability of 2,6-sulfonamide-substituted BODIPYs and its application to development of caged GABA"  Aoi Takeda, Toru Komatsu, Hiroshi Nomura, Naka Masamitsu, Norio Matsuki, Yuji Ikegaya, Takuya Terai, Tasuku Ueno, Kenjiro Hanaoka, Tetsuo Nagano, and Yasuteru Urano
  

  ChemBioChem

  , 17, 1-9 (2016)  doi:10.1002/cbic.201600097
  Note: Selected for cover article doi:10.1002/cbic.201600325
• "Broad-spectrum Antimicrobial Photocatalysis Mediated by Titanium Dioxide and UVA is Potentiated by Addition of Bromide Ion via Formation of Hypobromite" Ximing Wua, Ying-Ying Huang, Yu Kushida, Brijesh Bhayana, and Michael R. Hamblin
  

  Free Radic. Biol. Med.

  , 95, 74-81 (2016).  doi:10.1016/j.freeradbiomed.2016.03.012
• "Detection of NAD(P)H-dependent Enzyme Activity by Time-domain Ratiometry of Terbium Luminescence"  Takuya Terai, Hiroki Ito, Kenjiro Hanaoka, Toru Komatsu, Tasuku Ueno, Tetsuo Nagano, Yasuteru Urano
  

  Bioorg. Med. Chem. Lett.,

  6, 2314–2317, 2016,  doi:doi:10.1016/j.bmcl.2016.03.038
• "Discovery of pyruvylated peptide-metabolizing enzyme using a fluorescent substrate-based protein discovery technique"  Kentaro Yoshioka, Toru Komatsu, Kenjiro Hanaoka, Tasuku Ueno, Takuya Terai, Tetsuo Nagano, and Yasuteru Urano
  

  Chem. Commun.,

  52, 4377-4380 (2016)  doi:10.1039/C6CC00829A
• "A Protein-Coupled Fluorescent Probe to Visualize Potassium Ion Transition on Cellular Membranes"  Tomoya Hirata, Takuya Terai, HisaoYamamura, Manabu Shimonishi, Toru Komatsu, Kenjiro Hanaoka, Tasuku Ueno, Yuji Imaizumi, Tetsuo Nagano, and Yasuteru Urano
  

  Anal. Chem.,

   88, 2693–2700 (2016)  doi:10.1021/acs.analchem.5b03970
• "Editorial overview:Molecular Imaging Section"
  Yasuteru Urano, Ji-Xin Cheng
  

  Curr Opin Chem Biol.,

   33, Pages v (2016)  doi:10.1016/j.cbpa.2016.08.007
• "ICBS and ECBS Chemical Biology Meeting 2015 - Let Them Come to Berlin"
  Toru Komatsu and Satpal Virdee
  

  ACS Chem. Biol.

  , 11, 1159-1166 (2016)  doi:10.1021/acschembio.6b00268
• "Toward Total Synthesis of Cell Function: Reconstituting Cell Dynamics with Synthetic Biology"  Allen K. Kim, Robert DeRose, Tasuku Ueno, Benjamin Lin, Toru Komatsu, Hideki Nakamura, and Takanari Inoue
  

  Sci. Signaling

  , 9, re1 (2016)  doi:10.1126/scisignal.aac4779
• "Chemical Tools for The Study of Hydrogen Sulfide (H₂S) and Sulfane Sulfur and Their Applications to Biological Studies."  Yoko Takano, Kazuhito Shimamoto, Kenjiro Hanaoka
  

  J. Clin. Biochem. Nutr.,

    58, 7-15 (2016)  doi:10.3164/jcbn.15-91
• "ケイ素置換キサンテン蛍光団の創製と蛍光プローブへの応用"
  花岡 健二郎、浦野 泰照　　有機合成化学協会誌　Vol.74, No.5, pp512-520 (2016)
• "第24章　ケミカルバイオロジーの最前線　細胞の中で生きた酵素の働きを「見る」"
  小松徹，浦野泰照　　天然物の化学（科学のとびら６０），東京化学同人 (2016)



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