プロフィール

橘　椋　〔たちばな　りょう〕Ryo Tachibana

橘椋

主な研究テーマ

1. 計算化学に基づく合理的な機能性小分子デザイン法の開発
Development of Rational Methods for Functional Small Molecule Design Based on Computational Chemistry
2. 能動的数理最適化を活用した定量的かつ自律的な機能性小分子・医療技術開発
Quantitative and Autonomous Development of Functional Small Molecules and Medical Technologies Using Active Mathematical Optimization

略歴

2024年10月
 ～2027年3月
2024 Oct. - 2027 Mar.		 科学技術振興機構さきがけ「AI・ロボットによる研究開発プロセス革新のための基盤構築と実践活用」領域研究員（兼任）
JST PRESTO "R&D Process Innovation by AI and Robotics: Technical Foundations and Practical Applications" Researcher（concurrent appointment）
2023年4月
2023 Apr.		 東京大学大学院薬学系研究科　助教（現職
Assistant Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo (Current Position)
2020年4月
2020 Apr. - 2023 Mar.
 ～2023年3月		 博士研究員（海外）, バーゼル大学　化学科（Prof. Dr. Thomas R. Ward）
Postdoc, University of Basel, Department of Chemistry（Prof. Dr. Thomas R. Ward）
2020年3月
2020 Mar.		 東京大学　大学院薬学系研究科　博士課程修了・博士（薬科学）取得
Ph.D.(Pharmaceutical Sciences), University of Tokyo, Graduate School of Pharmaceutical Sciences
2017年4月
 ～2020年3月
2017 Apr. - 2020 Mar.		 日本学術振興会特別研究員（DC1）
JSPS Research Fellowships for Young Scientists (DC1)
2017年3月
2017 Mar.		 東京大学　大学院薬学系研究科　修士課程修了
Master, University of Tokyo, Graduate School of Pharmaceutical Sciences
2015年3月
2015 Mar.		 東京大学　薬学部　卒業
Bachelor, University of Tokyo, Faculty of Pharmaceutical Sciences

最近の成果

    【計算化学 Computational Chemistry】
  1. "Design of Antigen-Targeting Fluorogenic Probes Utilizing Intramolecular Addition Reaction of Protein-Dye Hybrids"   Mamiko Nakadate, Ryosuke Kojima, Naoki Seike, Ryo Tachibana, Kyohhei Fujita, Reiko Tsuchiya, Mako Kamiya, Andreas Plückthun and Yasuteru Urano, Journal of the American Chemical Society 147, 34, 30684-30693 (2025)
  2. "An evolved artificial radical cyclase enables the construction of bicyclic terpenoid scaffolds via an H-atom transfer pathway"   Dongping Chen, Xiang Zhang, Anastassia Andreevna Vorobieva, Ryo Tachibana, Alina Stein, Roman P. Jakob, Zhi Zou, Damian Alexander Graf, Ang Li, Timm Maier, Bruno E. Correia and Thomas R. Ward, Nature Chemistry 16, 1656-1664 (2024)
  3. "An Artificial [Fe₄S₄]-Containing Metalloenzyme for the Reduction of CO₂ to Hydrocarbons"   Valerie Waser, Manjistha Mukherjee, Ryo Tachibana, Nico V. Igareta and Thomas R. Ward, Journal of the American Chemical Society 145, 27, 14823-14830 (2023)
  4. "Manganese Transfer Hydrogenases Based on the Biotin-Streptavidin Technology"   Weijin Wang, Ryo Tachibana, Zhi Zou, Dongping Chen, Xiang Zhang, Kelvin Lau, Florence Pojer, Thomas R. Ward and Xile Hu, Angewandte Chemie International Edition e202311896 (2023)
  5. "Design of spontaneously blinking fluorophores for live-cell super-resolution imaging based on quantum-chemical calculations"   Ryo Tachibana, Mako Kamiya, Akihiko Morozumi, Yoshiyuki Miyazaki, Hiroyoshi Fujioka, Aika Nanjo, Ryosuke Kojima, Toru Komatsu, Tasuku Ueno, Kenjiro Hanaoka, Toshitada Yoshihara, Seiji Tobita and Yasuteru Urano, Chemical Communications 56, 13173-13176 (2020)
  6. "Molecular design strategy of fluorogenic probes based on quantum chemical prediction of intramolecular spirocyclization"   Ryo Tachibana, Mako Kamiya, Satoshi Suzuki, Keiji Morokuma, Aika Nanjo and Yasuteru Urano, Communications Chemistry 3, 82 (2020)
    7. 【能動的数理最適化 Active Mathematical Optimization】
  7. "Enhanced Sequence-Activity Mapping and Evolution of Artificial Metalloenzymes by Active Learning"   Tobias Vornholt, Mojmír Mutný, Gregor W. Schmidt, Christian Schellhaas, Ryo Tachibana, Sven Panke, Thomas R. Ward, Andreas Krause, Andreas Krause and Markus Jeschek, ACS Central Science 10, 7, 1357-1370 (2024)
  8. "A customized Bayesian algorithm to optimize enzyme-catalyzed reactions"   Ryo Tachibana, Kailin Zhang, Zhi Zou, Simon Burgener and Thomas R. Ward, ACS Sustainable Chemistry & Engineering 11(33), 12336-12344 (2023)