研究業績 Publications

Archive by Year

2010年

  • "Hypoxia-sensitive Fluorescent Probes for in vivo Real-time Fluorescence Imaging of Acute Ischemia" Kazuki Kiyose, Kenjiro Hanaoka, Daihi Oushiki, Tomomi Nakamura, Mayumi Kajimura, Makoto Suematsu, Hiroaki Nishimatsu, Takehiro Yamane, Takuya Terai, Yasunobu Hirata and Tetsuo Nagano, J. Am. Chem. Soc., 132, 15846-15848 (2010).
  • "A Time-Resolved Fluorescence Probe for Dipeptidyl Peptidase 4 and its Application for Inhibitor Screening" Mitsuyasu Kawaguchi, Takayoshi Okabe, Takuya Terai, Kenjiro Hanaoka, Hirotatsu Kojima, Izumi Minegishi and Tetsuo Nagano, Chemistry-A European Journal, 16, 13479-13486 (2010).
  • "Development of Luciferin Analogues Bearing an Amino Group and Their Application as BRET Donors" Hideo Takakura, Kiyoshi Sasakura, Tasuku Ueno, Yasuteru Urano, Takuya Terai, Kenjiro Hanaoka, Takashi Tsuboi and Tetsuo Nagano, Chemistry-An Asian Journal, 5, 2053-2061 (2010).
  • "Sensitive Detection of Acrolein in Serum Using Time-resolved Luminescence" Masataka Togashi, Yasuteru Urano, Hirotatsu Kojima, Takuya Terai, Kejiro Hanaoka, Kazuei Igarashi, Yasunobu Hirata and Tetsuo Nagano, Organic Letters, 12, 1704-1707 (2010).
  • "Development and Application of a Near-infrared Fluorescence Probe for Oxidative Stress Based on Differential Reactivity of Linked Cyanine Dyes" Daihi Oushiki, Hirotatsu Kojima, Takuya Terai, Makoto Arita, Kenjiro Hanaoka, Yasuteru Urano and Tetsuo Nagano, J. Am. Chem. Soc., 132, 2795-2801 (2010).
  • "Design and Synthesis of a Highly Sensitive Off-On Fluorescent Chemosensor for Zinc Ion Utilizing Internal Charge Transfer" Kenjiro Hanaoka, Yasuaki Muramatsu, Yasuteru Urano, Takuya Terai and Tetsuo Nagano, Chemistry - A European Journal, 16, 568-572 (2010).

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2009年

  • "Development of 2,6-Carboxy-Substituted Boron Dipyrromethene (BODIPY) as a Novel Scaffold of Ratiometric Fluorescent Probes for Live Cell Imaging" Toru Komatsu, Yasuteru Urano, Yuuta Fujikawa, Tomonori Kobayashi, Hirotatsu Kojima, Takuya Terai, Kenjiro Hanaoka and Tetsuo Nagano, Chem. Comm., 7015-7017 (2009).
  • "A Simple and Effective Strategy to Increase the Sensitivity of Fluorescence Probes in Living Cells" Saki Izumi, Yasuteru Urano, Kenjiro Hanaoka, Takuya Terai and Tetsuo Nagano, J. Am. Chem. Soc., 131, 10189-10200 (2009).
  • "Molecular Design Strategies for Near-infrared Ratiometric Fluorescent Probes Based on Unique Spectral Properties of Aminocyanines" Kazuki Kiyose, Sakiko Aizawa, Eita Sasaki, Hirotatsu Kojima, Yasuteru Urano, Kejiro Hanaoka, Takuya Terai and Tetsuo Nagano, Chemistry - A European Journal, 15, 9191-9200 (2009).
  • "Design and Development of Enzymatically Activatable Photosensitizer Based on Unique Characteristics of Thiazole Orange" Yuichiro Koide, Yasuteru Urano, Akira Yatsushige, Kenjiro Hanaoka, Takuya Terai and Tetsuo Nagano, J. Am. Chem. Soc., 131, 6058-6059 (2009).
  • "MRI用センサー分子の分子設計・化学合成"　長野哲雄、花岡健二郎、化学フロンティア：新しい地平をひらく分析手法の最前線、化学同人、69-76 (2009)
  • "分子の蛍光性制御と蛍光プローブ開発1, 2 & 3"　上野　匡、長野哲雄、「薬学分析科学の最前線」日本薬学会物理系薬学部会分析化学担当教員会議編、（株）じほう、162-167 (2009).

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2008年

  • "Fluorescent Probes for Bioimaging Applications" Takuya Terai and Tetsuo Nagano, Current Opinion in Chemical Biology, 12,515-521 (2008).
  • "Design and Synthesis of Highly Sensitive Fluorogenic Substrates for Glutathione S-transferase (GST) and Application for Activity Imaging in Living Cells" Yuuta Fujikawa, Yasuteru Urano, Toru Komatsu, Kenjiro Hanaoka, Hirotatsu Kojima, Takuya Terai, Hideshi Inoue and Tetsuo Nagano, J. Am. Chem. Soc.,130, 14533-14543 (2008).
  • "Development of a Novel Fluorescent Probe for Fluorescence Correlation Spectroscopic Detection of Kinase Inhibitors" Mitsuyasu Kawaguchi, Takuya Terai, Rei Utata, Miki Kato, Keiko Tsuganezawa, Akiko Tanaka, Hirotatsu Kojima, Takayosi Okabe and Tetsuo Nagano, Bioorganic & Medicinal Chemistry Letters, 18, 3752-3755 (2008).
  • "The detection limit of a Gd3+ -based T1 agent is substantially reduced when targeted to a protein microdomain" Kenjiro Hanaoka, Angelo Josue M. Lubag, Aminta Castillo-Muzquiz, Thomas Kodadek, A. Dean Sherry, Magnetic Resonance Imaging, 26, 608-617 (2008).
  • "A Gd3+-Based Magnetic Resonance Imaging Contrast Agent Sensitive to beta-Galactosidase Activity Utilizing a Receptor-Induced Magnetization Enhancement (RIME) Phenomenon" Kenjiro Hanaoka, Kazuya Kikuchi, Takuya Terai, Toru Komatsu and Tetsuo Nagano, Chemistry - A European Journal, 14, 987-995 （2008）.
  • "MRI用センサー分子の分子設計・化学合成"　長野哲雄、花岡健二郎、化学フロンティア：切り拓き、サイエンスを牽引する分析最前線 化学同人、 印刷中.
  • "ケミカルバイオロジー研究"　東京大学創立130周年記念出版物「アカデミック・グルーブ」、東京大学出版会、30-31 (2008)
  • "光イメージングとイメージングプローブ"　分子イメージング学会、Vol. 1(No. 1) (2008)
  • "巻頭言：日本におけるケミカルバイオロジー研究を考える"　日本ケミカルバイオロジー研究会会員誌、Vol. 1(No. 1) (2008)

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2007年

  • "Site-Specific Oxidative Stress Induction" Takuya Terai and Tetsuo Nagano, Chemistry & Biology (Previews), 14, 877-878 (2007).
  • "Time-Resolved Long-Lived Luminescence Imaging Method Employing Luminescent Lanthanide Probes with a New Microscopy System" Kenjiro Hanaoka, Kazuya Kikuchi, Shigeru Kobayashi and Tetsuo Nagano, J. Am. Chem. Soc., 129, 13502-13509 (2007).
  • "Development of an Iminocoumarin-Based Zinc Sensor Suitable for Ratiometric Fluorescence Imaging of Neuronal Zinc" Kensuke Komatsu,Yasuteru Urano, Hirotatsu Kojima and Tetsuo Nagano, J. Am. Chem. Soc., 129, 13447-13454 (2007).
  • "Design and Synthesis of a Library of BODIPY-Based Environmental Polarity Sensors Utilizing Photoinduced Electron Transfer-Controlled Fluorescence ON/OFF Switching" Hisato Sunahara, Yasuteru Urano, Hirotatsu Kojima, and Tetsuo Nagano, J. Am. Chem. Soc., 129, 5597-5604 (2007).
  • "蛍光標識法　～蛍光で生体分子を光らせる～"　上野　匡、浅沼大祐、長野哲雄、実験医学別冊実験ハンドブックシリーズ「生命科学のための機器分析実験ハンドブック」（西村善文編集）、pp. 27-34 (2007).
  • "分子イメージングプローブの開発"　上野　匡、浦野泰照、長野哲雄、日本臨床、65，247-252（2007）.

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2006年

  • "Design and Synthesis of an Enzyme Activity-Based Labeling Molecule with Fluorescence Spectral Change" Toru Komatsu, Kazuya Kikuchi, Hideo Takakusa, Kenjiro Hanaoka, Tasuku Ueno, Mako Kamiya, Yasuteru Urano and Tetsuo Nagano, J. Am. Chem. Soc., 128，15946-15947（2006）.
  • "Creation of Superior Carboxyfluorescein Dyes by Blocking Donor-Excited Photoinduced Electron Transfer" Tomoko Mineno, Tasuku Ueno, Yasuteru Urano, Hirotatsu Kojima and Tetsuo Nagano, Org. Lett., 8，5963-5966（2006）.
  • "Mechanism-Based Molecular Design of Highly Selective Fluorescence Probes for　Nitrative Stress" Tasuku Ueno, Yasuteru Urano, Hirotatsu Kojima and Tetsuo Nagano. J. Am. Chem. Soc., 128, 10640-10641 (2006).
  • "Tunable Design Strategy for Fluorescence Probes Based on 4-Substituted BODIPY Chromophore; Improvement of Highly Sensitive Fluorescence Probe for Nitric Oxide" Yu Gabe, Tasuku Ueno, Yasuteru Urano, Hirotatsu Kojima and Tetsuo Nagano, Analytical and Bioanalytical Chemistry, 386，621-626（2006）.
  • "Modulation of Luminescence Intensity of Lanthanide Complexes by Photoinduced Electron Transfer and Its Application to a Long-Lived Protease Probe" Takuya Terai, Kazuya Kikuchi, Shin-ya Iwasawa, Takao Kawabe, Yasunobu Hirata, Yasuteru Urano and Tetsuo Nagano, J. Am. Chem. Soc., 128, 6938-6946 (2006).
  • "世界初のケミカルバイオロジー研究会年会"　細胞工学、25, 1050-1052 (2006).
  • "蛍光プローブ　－ランタノイド金属の蛍光を用いた高感度臨床診断薬の開発－"　長野哲雄、寺井琢也、脈管学、46、743-748　（2006）.

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