2015年
- "Azobenzene-caged Sulforhodamine Dyes: a Novel Class of ‘turn-on’ Reactive Probes for Hypoxic Tumor Cell Imaging" Arnaud Chevalier, Wen Piao, Kenjiro Hanaoka, Tetsuo Nagano, Pierre-Yves Renard and Anthony Romieu
Methods Appl. Fluoresc.
, 3, 044004 (2015) doi:10.1088/2050-6120/3/4/044004 - "Development of a Sensitive Bioluminogenic Probe for Imaging Highly Reactive Oxygen Species in Living Rats" Ryosuke Kojima, Hideo Takakura, Mako Kamiya, Eiji Kobayashi, Toru Komatsu, Tasuku Ueno, Takuya Terai, Kenjiro Hanaoka, Tetsuo Nagano, and Yasuteru Urano
Angew. Chem. Int. Ed.,
54, 14768–14771 (2015) doi:10.1002/anie.201507530 & doi:10.1002/ange.201507530 - "Identification of tissue-restricted bio-reaction suitable for in vivo targeting by fluorescent substrate library-based enzyme discovery" Kentaro Yoshioka, Toru Komatsu, Akihiro Nakada, Jun Onagi, Yugo Kuriki, Mitsuyasu Kawaguchi, Takuya Terai, Tasuku Ueno, Kenjiro Hanaoka, Tetsuo Nagano, and Yasuteru Urano
J. Am. Chem. Soc.,
137, 12187-12190 (2015) doi:10.1021/jacs.5b05884 - "Artificial Ligands of Streptavidin (ALiS): Discovery, Characterization, and Application for Reversible Control of Intracellular Protein Transport" Takuya Terai, Moe Kohno, Gaelle Boncompain, Shigeru Sugiyama, Nae Saito, Ryo Fujikake, Tasuku Ueno, Toru Komatsu, Kenjiro Hanaoka, Takayoshi Okabe, Yasuteru Urano, Franck Perez, and Tetsuo Nagano
J. Am. Chem. Soc.,
137, 10464–10467 (2015) doi:10.1021/jacs.5b05672 - "Analysis of Chemical Equilibrium of Si-substituted Fluorescein and its Application to Develop a Scaffold for Red Fluorescent Probes" Kazuhisa Hirabayashi, Kenjiro Hanaoka, Toshio Takayanagi, Yuko Toki, Takahiro Egawa, Mako Kamiya, Toru Komatsu, Tasuku Ueno, Takuya Terai, Kengo Yoshida, Masanobu Uchiyama, Tetsuo Nagano, and Yasuteru Urano
Anal. Chem.,
87, 9061–9069 (2015) doi:10.1021/acs.analchem.5b02331 - "Detection of NAD(P)H-dependent Enzyme Activity with Dynamic Luminescence
Quenching of Terbium Complexes" Hiroki Ito, Takuya Terai, Kenjiro Hanaoka, Tasuku Ueno, Toru Komatsu, Tetsuo Nagano and Yasuteru Urano
Chem. Commun.,
51, 8319-8322 (2015) doi:10.1039/c5cc01613d - "Sensitive β-galactosidase-targeting fluorescence probe for visualizing small peritoneal metastatic tumours in vivo." Daisuke Asanuma, Masayo Sakabe, Mako Kamiya, Kyoko Yamamoto, Jun Hiratake, Mikako Ogawa, Nobuyuki Kosaka, Peter L. Choyke, Tetsuo Nagano, Hisataka Kobayashi and Yasuteru Urano
Nat. Commun.,
6, Article number:6463 (2015) doi:10.1038/ncomms7463 - "Development of a Series of Near-infrared Dark Quenchers Based on Si-rhodamines and Their Application to Fluorescent Probes" Takuya Myochin, Kenjiro Hanaoka, Shimpei Iwaki, Tasuku Ueno, Toru Komatsu, Takuya Terai, Tetsuo Nagano, and Yasuteru Urano
J. Am. Chem. Soc.,
137, 4759-4765 (2015) doi:10.1021/jacs.5b00246 - "New Class of Bioluminogenic Probe Based on Bioluminescent Enzyme-induced Electron Transfer: BioLeT" Hideo Takakura, Ryosuke Kojima, Mako Kamiya, Eiji Kobayashi, Toru Komatsu, Tasuku Ueno, Takuya Terai, Kenjiro Hanaoka, Tetsuo Nagano, and Yasuteru Urano
J. Am. Chem. Soc.,
137, 4010-4013 (2015) doi:10.1021/ja511014w -
"Gliotoxin Suppresses NF-κB Activation by Selectively Inhibiting Linear Ubiquitin Chain Assembly Complex (LUBAC)" Hiroki Sakamoto, Shinichiro Egashira, Nae Saito, Takayoshi Kirisako, Simon Miller, Yoshiteru Sasaki, Tadahiko Matsumoto, Manabu Shimonishi, Toru Komatsu, Takuya Terai, Tasuku Ueno, Kenjiro Hanaoka, Hirotatsu Kojima, Takayoshi Okabe, Soichi Wakatsuki, Kazuhiro Iwai, and Tetsuo Nagano
ACS Chem. Biol.,
10, 675-681 (2015) doi:10.1021/cb500653y - "Fluorescent Probes for Hydrogen Sulfide (H2S) and Sulfane Sulfur and Their Applications to Biological Studies" Kazuhito Shimamoto and Kenjiro Hanaoka
Nitric Oxide,
46, 72-79 (2015) doi:10.1016/j.niox.2014.11.008 - "Development of Photo-controllable Hydrogen Sulfide Donor Applicable in Live Cells" Naoki Fukushima, Naoya Ieda, Mitsuyasu Kawaguchi, Kiyoshi Sasakura, Tetsuo Nagano, Kenjiro Hanaoka, Naoki Miyata, Hidehiko Nakagawa
Bioorg. Med. Chem. Lett.,
25, 175-178 (2015) doi:10.1016/j.bmcl.2014.11.084 - "Compartmentalized AMPK Signaling Illuminated by Genetically Encoded Molecular Sensors and Actuators" Takafumi Miyamoto, Elmer Rho, Vedangi Sample, Hiroki Akano, Masaki Magari, Tasuku Ueno, Kirill Gorshkov, Melinda Chen, Hiroshi Tokumitsu, Jin Zhang, Takanari Inoue
Cell Reports
11, 657-670 (2015) doi:10.1016/j.celrep.2015.03.057 - "Silicon-substituted Xanthene Dyes and Their Applications in Bioimaging"
Yu Kushida, Tetsuo Nagano and Kenjiro Hanaoka
Analyst,
140, 685-695 (2015) doi:10.1039/c4an01172d - "Evaluation of Enzymatic Activities in Living Systems with Small-molecular Fluorescent Substrate Probes" Toru Komatsu and Yasuteru Urano
Anal. Sci.,
31, 257-265 (2015) doi:10.2116/analsci.31.257
2014年
- "Fluorometric Assay of Integrin Activity with a Small-molecular Probe that Senses the Binding Site Microenvironment" Toru Komatsu, Aoi Takeda, Kenjiro Hanaoka, Takuya Terai, Tasuku Ueno, Yukio Tada, Tetsuo Nagano and Yasuteru Urano
Chem. Commun.,
50, 15894-15896 (2014) doi:10.1039/C4CC05591H - "Cytoprotective Effects of Hydrogen Sulfide-releasing N-Methyl-D-aspartate Receptor Antagonists Mediated by Intracellular Sulfane Sulfur" Eizo Marutani, Masahiro Sakaguchi, Wei Chen, Kiyoshi Sasakura, Jifeng Liu, Ming Xian, Kenjiro Hanaoka, Tetsuo Nagano and Fumito Ichinose
Med. Chem. Commun.,
5, 1577-1583 (2014) doi:10.1039/C4MD00180J - "Boron Dipyrromethene as a Fluorescent Caging Group for Single-photon Uncaging with Long-wavelength Visible Light" Nobuhiro Umeda, Hironori Takahashi, Mako Kamiya, Tasuku Ueno, Toru Komatsu, Takuya Terai, Kenjiro Hanaoka, Tetsuo Nagano, and Yasuteru Urano
ACS Chem. Biol.,
9, 2242-2246 (2014) doi:10.1021/cb500525p - "Design Strategy for Small Molecule-based Targeted MRI Contrast Agents: Application for Detection of Atherosclerotic Plaques" Shimpei Iwaki, Kazuya Hokamura, Mikako Ogawa, Yasuo Takehara, Yasuaki Muramatsu, Takehiro Yamane, Kazuhisa Hirabayashi, Yuji Morimoto, Kohsuke Hagisawa, Kazuhide Nakahara, Tomoko Mineno, Takuya Terai, Toru Komatsu, Tasuku Ueno, Keita Tamura, Yusuke Adachi, Yasunobu Hirata, Makoto Arita, Hiroyuki Arai, Kazuo Umemura, Tetsuo Nagano and Kenjiro Hanaoka
Org. Biomol. Chem.,
12, 8611-8618 (2014) doi:10.1039/C4OB01270D - "A Spontaneously Blinking Fluorophore Based on Intramolecular Spirocyclization for Live-cell Super-resolution Imaging" Shin-nosuke Uno, Mako Kamiya, Toshitada Yoshihara, Ko Sugawara, Kohki Okabe, Mehmet C. Tarhan, Hiroyuki Fujita, Takashi Funatsu, Yasushi Okada, Seiji Tobita and Yasuteru Urano
Nat. Chem.,
6, 681–689 (2014) doi:10.1038/nchem.2002 - "Arrayed lipid bilayer chambers allow single-molecule analysis of membrane transporter activity" Rikiya Watanabe, Naoki Soga, Daishi Fujita, Kazuhito V. Tabata, Lisa Yamauchi, Soo Hyeon Kim, Daisuke Asanuma, Mako Kamiya, Yasuteru Urano, Hiroaki Suga and Hiroyuki Noji
Nat. Commun.,
5, Article number: 4519 (2014) doi:10.1038/ncomms5519 - "Rapidly Rendering Cells Phagocytic Through a Cell-surface Display Technique and Concurrent Rac Activation" Hiroki Onuma, Toru Komatsu, Makoto Arita, Kenjiro Hanaoka , Tasuku Ueno, Takuya Terai, Tetsuo Nagano and Takanari Inoue.
Sci. Signaling,
7, 334, rs4 (2014) doi:10.1126/scisignal.2005123 - "Practical Fluorescence Detection of Acrolein in Human Plasma via a Two-step Tethering Approach" Masataka Togashi, Takuya Terai, Hirotatsu Kojima, Kenjiro Hanaoka, Kazuei Igarashi, Yasunobu Hirata, Yasuteru Urano,* and Tetsuo Nagano,
Chem. Commun.,
50, 14946-14948 (2014) doi:10.1039/C4CC02578D - "Visualization of Phagosomal Hydrogen Peroxide Production by A Novel Fluorescent Probe That Is Localized via SNAP-tag Labeling" Masahiro Abo, Reiko Minakami, Kei Miyano, Mako Kamiya, Tetsuo Nagano, Yasuteru Urano, and Hideki Sumimoto
Anal. Chem.,
86, 5983-5990, (2014) doi:10.1021/ac501041w - "Thermal or Mechanical Stimuli-induced Photoluminescence Color Change of Molecular Assembly Composed of An Amphiphilic Anthracene Derivative in Water" Yoshimitsu Sagara, Toru Komatsu, Takuya Terai, Tasuku Ueno, Kenjiro Hanaoka, Takashi Kato, and Tetsuo Nagano.
Chem. Eur. J.,
20, 10397–10403 (2014) doi:10.1002/chem.201403025 - "Selective Ablation of β-Galactosidase-expressing Cells with a Rationally Designed Activatable Photosensitizer." Yuki Ichikawa, Mako Kamiya, Fumiaki Obata, Masayuki Miura, Takuya Terai, Toru Komatsu, Tasuku Ueno, Kenjiro Hanaoka, Tetsuo Nagano, Yasuteru Urano.
Angew. Chem. Int. Ed.,
53, 6772-6775 (2014) doi:10.1002/anie.201403221 - "Acidic-pH-activatable Fluorescence Probes for Visualizing Exocytosis Dynamics" Daisuke Asanuma, Takaoka, Y.; Shigeyuki Namiki, Kenji Takikawa, Mako Kamiya, Tetsuo Nagano, Yasuteru Urano, and Kenzo Hirose.
Angew. Chem. Int. Ed.,
126, 6199-6203 (2014) doi:10.1002/ange.201402030 - "Bin/Amphyphisin/Rvs(Bar) Family Members Bend Membrane in Cells" Allison Suaraz, Tasuku Ueno, Robert Huebner, J. Michael McCaffey and Takanari Inoue.
Sci. Report,
4, Article number:4693 (2014) doi:10.1038/srep04693 - "Primary hepatocytes from mice lacking cysteine dioxygenase show increased cysteine concentrations and higher rates of metabolism of cysteine to hydrogen sulfide and thiosulfate" Halina Jurkowska, Heather B. Roman, Lawrence L. Hirschberger, Kiyoshi Sasakura,
Tetsuo Nagano, Kenjiro Hanaoka, Jakub Krijt and Martha H. Stipanuk
Amino Acids,
46, 1353-1365 (2014) doi:10.1007/s00726-014-1700-8 - "Covalent Attachment of Mechanoresponsive Luminescent Micelles to Glasses and Polymers in Aqueous Conditions" Yoshimitsu Sagara, Toru Komatsu, Tasuku Ueno, Kenjiro Hanaoka, Takashi Kato, and Tetsuo Nagano.
J. Am. Chem. Soc.,
136, 4273-4280 (2014) doi:10.1021/ja412670g - "Unbalanced excitability underlies offline reactivation of behaviorally activated neurons" Mika Mizunuma, Hiroaki Norimoto, Kentaro Tao,
Takahiro Egawa, Kenjiro Hanaoka, Tetsuya Sakaguchi,
Hiroyuki Hioki, Takeshi Kaneko, Shun Yamaguchi, Tetsuo Nagano, Norio Matsuki and Yuji Ikegaya.
Nat. Neurosci.,
17, 503-505 (2014) doi:10.1038/nn.3674 - "Synthesis of a photocontrollable hydrogen sulfide donor using ketoprofenate photocages" Naoki Fukushima, Naoya Ieda, Kiyoshi Sasakur, Tetsuo Nagano, Kenjiro Hanaok, Takayoshi Suzuki, Naoki Miyataa and Hidehiko Nakagawa
Chem. Commun.,
50, 587-589 (2014) doi:10.1039/C3CC47421F
2013年
- "Development of Azo-Based Fluorescent Probes to Detect Different Levels of Hypoxia" Wen Piao, Satoru Tsuda, Yuji Tanaka, Satoshi Maeda, Fengyi Liu, Shodai Takahashi, Yu Kushida, Toru Komatsu, Tasuku Ueno, Takuya Terai, Toru Nakazawa, Masanobu Uchiyama, Keiji Morokuma, Tetsuo Nagano, and Kenjiro Hanaoka,
Angew. Chem. Int. Ed.,
52, 13028-13032 (2013) doi:10.1002/anie.201305784 - "Diced Electrophoresis Gel Assay for Screening Enzymes with Specified Activities" Toru Komatsu, Kenjiro Hanaoka, Alexander Adibekian, Takuya
Terai, Tasuku Ueno, Mitsuyasu Kawaguchi, Benjamin Cravatt and Tetsuo
Nagano
J. Am. Chem. Soc.,
135, 6002-6005 (2013) doi:10.1021/ja401792d - "A Water-soluble Mechanochromic Luminescent Pyrene Derivative Exhibiting Recovery of the Initial Photoluminescence Color in a High-humidity Environment" Yoshimitsu Sagara, Toru Komatsu, Tasuku Ueno, Kenjiro Hanaoka, Takashi Kato and Tetsuo Nagano
Adv. Funct. Mater.,
23, 5277-5284 (2013) doi:10.1002/adfm.201300180 - "Small-molecule Fluorophores and Fluorescent Probes for Bioimaging" Takuya Terai and Tetsuo Nagano
Pflugers Arch - Eur. J. Physiol.,
465, 347–359 (2013) doi:10.1007/s00424-013-1234-z - "Red Fluorescence Probe for Monitoring Dynamics of Cytoplasmic Calcium Ion" Takahiro Egawa, Kazuhisa Hirabayashi, Yuichiro Koide, Chiaki Kobayashi, Naoya Takahashi, Tomoko Mineno, Takuya Terai, Tasuku Ueno, Toru Komatsu, Yuji Ikegaya, Norio Matsuki, Tetsuo Nagano and Kenjiro Hanaoka
Angew. Chem. Int. Ed.,
52, 38740-3877 (2013) doi:10.1002/anie.201210279 - "TokyoGreen Derivatives as Specific and Practical Fluorescent Probes for UDP-Glucuronosyltransferase (UGT) 1A1" Takuya Terai, Rie Tomiyasu, Tomoe Ota, Tasuku Ueno, Toru Komatsu, Kenjiro Hanaoka, Yasuteru Urano and Tetsuo Nagano
Chem. Commun.,
49, 3101-3103 (2013) doi:10.1039/C3CC38810G - "Rational Design and Development of Near-infrared-emitting Firefly Luciferins Available in vivo" Ryosuke Kojima, Hideo Takakura, Takeaki Ozawa, Yukio Tada, Tetsuo Nagano and Yasuteru Urano
Angew. Chem. Int. Ed.,
52, 1175-1179 (2013) doi:10.1002/anie.201205151 - "Rational Design of Highly Sensitive Fluorescence Probes For Protease and Glycosidase Based on Precisely Controlled Spirocyclization" Masayo Sakabe, Daisuke Asanuma, Mako Kamiya, Ryu Iwatate, Kenjiro Hanaoka, Takuya Terai, Tetsuo Nagano and Yasuteru Urano
J. Am. Chem. Soc.,
135, 409-414 (2013) doi:10.1021/ja309688m - "Synthesis of a photocontrollable hydrogen sulfide donor using ketoprofenate photocages"
Naoki Fukushima, Naoya Ieda, Kiyoshi Sasakura, Tetsuo Nagano, Kenjiro Hanaoka, Takayoshi Suzuki, Naoki Miyata Hidehiko Nakagawa
Chem. Commun.,
50, 587-589 (2013) doi:10.1039/C3CC47421F - "ケミカルバイオロジー - 成功事例から学ぶ研究戦略 -" 長野哲雄, 萩原正敏 監訳, 丸善出版 （2013）
- "創薬の標的分子探索の新技術" 小松 徹、長野 哲雄、MEDCHEM NEWS, 23,33-40 (2013).
2012年
- "Reversible Off-On Fluorescence Probe for Hypoxia and Imaging of Hypoxia-Normoxia Cycles in Live Cells" Shodai Takahashi, Wen Piao, Yuriko Matsumura, Toru Komatsu, Tasuku Ueno, Takuya Terai, Toshiaki Kamachi, Masahiro Kohno, Tetsuo Nagano and Kenjiro Hanaoka
J. Am. Chem. Soc.,
134, 19588-19591 (2012) doi:10.1021/ja310049d - "Design Strategy for a Near-infrared (NIR) Fluorescence Probe for Matrix Metalloproteinase Utilizing Highly Cell-permeable Boron Dipyrromethene (BODIPY)" Takuya Myochin, Kenjiro Hanaoka, Toru Komatsu, Takuya Terai and Tetsuo Nagano
J. Am. Chem. Soc.,
134, 13730-13737 (2012) doi:10.1021/ja303931b - "Highly Activatable and Environment-insensitive Optical Highlighters for Selective Spatiotemporal Imaging of Target Proteins" Tomonori Kobayashi, Toru Komatsu, Mako Kamiya, Cláudia Campos, Marcos González-Gaitán, Takuya Terai, Kenjiro Hanaoka, Tetsuo Nagano and Yasuteru Urano
J. Am. Chem. Soc.,
134, 11153-11160 (2012) doi:10.1021/ja212125w - "Red Fluorescent Scaffold for Highly Sensitive Protease Activity Probes" Yu Kushida, Kenjiro Hanaoka, Toru Komatsu, Takuya Terai, Tasuku Ueno, Kengo Yoshida, Masanobu Uchiyama, Tetsuo Nagano
Bioorg. Med. Chem. Lett.,
22, 3908-3911(2012) doi:10.1016/j.bmcl.2012.04.114 - "Development of 5’- and 7’-Substituted Luciferin Analogues as Acid-Tolerant Substrates of Firefly Luciferase" Hideo Takakura, Ryosuke Kojima, Takeaki Ozawa, Tetsuo Nagano and Yasuteru Urano
ChemBiolChem,
13, 1-4 (2012) doi:10.1002/cbic.201200142 - "Near-infrared Fluorescence Probes for Enzymes Based on Binding Affinity Modulation of Squarylium Dye Scaffold" Daihi Oushiki, Hirotatsu Kojima, Yuki Takahashi, Toru Komatsu, Takuya Terai, Kenjiro Hanaoka, Makiya Nishikawa, Yoshinobu Takakura and Tetsuo Nagano
Anal. Chem.,
84, 4404-4410 (2012) doi:10.1021/ac300061a - "Salicyclic Acid Derivatives as Antennae for Ratiometric Luminescent Probes Based on Lanthanide Complexes" Takuya Terai, Hiroki Ito, Kazuya Kikuchi, and Tetsuo Nagano
Chem. Eur. J.,
13, 7377-7381(2012) doi:10.1002/chem.201200610 - "Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells" Robert DeRose, Christopher Pohlmeyer, Nobuhiro Umeda, Tasuku Ueno, Tetsuo Nagano, Scot Kuo, and Takanari Inoue
J. Vis. Exp.,
, 61, e3794 (2012) doi:10.1002/chem.201200610 - "Development of NIR Fluorescent Dyes Based on Si-Rhodamine for In Vivo Imaging" Yuichiro Koide, Yasuteru Urano, Kenjiro Hanaoka, Wen Piao, Moriaki Kusakabe, Nae Saito, Takuya Terai, Takayoshi Okabe and Tetsuo Nagano
J. Am. Chem. Soc.,
134, 5029-5031 (2012) doi:10.1021/ja210375e - "Development of of hypoxia-sensitive Gd3+-based MRI contrast agents" Shimpei Iwaki, Kenjiro Hanaoka, Wen Piao, Toru Komatsu, Tasuku Ueno, Takuya Terai and Tetsuo Nagano
Bioorg. Med. Chem. Lett.,
22, 2798-2802 (2012) doi:10.1016/j.bmcl.2012.02.071 - "A Reversible Near-Infrared Fluorescence Probe for Reactive Oxygen Species Based on Te-rhodamine" Yuichiro Koide, Mitsuyasu Kawaguchi, Yasuteru Urano, Kenjiro Hanaoka, Toru Komatsu, Takuya Terai and Tetsuo Nagano
Chem. Commun.,
48, 3091-3093 (2012) doi:10.1039/C2CC18011A - "A Long-Lived Luminescent Probe to Sensitively Detect Arylamine N-Acetyltransferase (NAT) Activity of Cells" Takuya Terai, Kazuya Kikuchi, Yasuteru Urano, Hirotatsu Kojima and Tetsuo Nagano
Chem. Commun.,
, 48, 2234-2236(2012) doi:10.1039/C2CC17622J - "A Practical Strategy to Create Near-Infrared Luminescent Probes: Conversion from Fluorescein-Based Sensors" Takuya Terai, Yasuteru Urano, Saki Izumi, Hirotatsu Kojima and Tetsuo Nagano
Chem. Commun.,
48, 2840-2842 (2012) doi:10.1039/C2CC16553H - "機能性MRI造影剤の分子設計および動脈硬化イメージング" 花岡健二郎, 『疾患克服を目指したケミカルバイオロジー』、実験医学(増刊号), 30, 1120-1127 (2012)
- "3章 バイオセンシングの歴史と将来展望" 花岡健二郎、長野哲雄, 『CSJカレントレビュー第10巻 ここまで進んだバイオセンシング・イメージング』 化学同人、日本化学会編, pp15-19 (2012).
- "創薬研究への応用を目指した蛍光プローブの開発" 寺井琢也、長野哲雄, 化学工業, 63, 47-53 (2012)
2011年
- "Activatable Optical Imaging with a Silica-Rhodamine Based Near Infrared (SiR700) Fluorophore: A comparison with cyanine based dyes" Thomas E. McCann, Nobuyuki Kosaka, Yuichiro Koide, Makoto Mitsunaga, Peter L. Choyke, Tetsuo Nagano, Yasuteru Urano and Hisataka Kobayashi
Bioconjugate Chem.,
22, 2531-2538 (2011) doi:10.1021/bc2003617 - "Development of a Highly Selective Fluorescence Probe for Hydrogen Sulfide" Kiyoshi Sasakura, Kenjiro Hanaoka, Norihiro Shibuya, Yoshinori Mikami, Yuka Kimura, Toru Komatsu, Tasuku Ueno, Takuya Terai, Hideo Kimura, and Tetsuo Nagano
J. Am. Chem. Soc.,
133, 18003-18005 (2011) doi:10.1021/ja207851s - "Selective Two-Step Labeling of Proteins with an Off-On Fluorescence Probe" Kazuhisa Hirabayashi, Kenjiro Hanaoka, Manabu Shimonishi, Takuya Terai, Toru Komatsu, Tasuku Ueno and Tetsuo Nagano
Chem. Eur. J.,
17, 14763-14771 (2011) doi:10.1002/chem.201102664 - "Method for Enhancing Cell-penetration of Gd3+-based MRI Contrast Agents by Conjugation with Hydrophobic Fluorescent Dyes" Takehiro Yamane, Kenjiro Hanaoka, Yasuaki Muramatsu, Keita Tamura, Yusuke Adachi, Yasushi Miyashita, Yasunobu Hirata and Tetsuo Nagano
Bioconjugate Chem.,
22, 2227-2236 (2011) doi:10.1021/bc200127t - "Development of a Potassium Ion-Selective Fluorescent Sensor Based on 3-Styrylated BODIPY" Tomoya Hirata, Takuya Terai, Toru Komatsu, Kenjiro Hanaoka and Tetsuo Nagano
Bioorg. Med. Chem. Lett.,
21, 6090-6093 (2011) doi:10.1016/j.bmcl.2011.08.056 - "Development of a Far-Red to Near-Infrared Fluorescence Probe for Calcium Ion and its Application to Multicolor Neuronal Imaging" Takahiro Egawa, Kenjiro Hanaoka, Yuichiro Koide, Sakiko Ujita, Naoya Takahashi, Yuji Ikegaya, Norio Matsuki, Takuya Terai, Tasuku Ueno, Toru Komatsu and Tetsuo Nagano
J. Am. Chem. Soc.,
133, 14157-14159 (2011) doi:10.1021/ja205809h - "Rational Development of Caged-Biotin Protein-Labeling Agents and Some Applications in Live Cells" Takuya Terai, Eri Maki, Shigeru Sugiyama, Yoshinori Takahashi, Hiroyoshi Matsumura, Yusuke Mori and Tetsuo Nagano
Chem. Biol.,
18, 1261-1272 (2011) doi:10.1016/j.chembiol.2011.09.007 - "β-Galactosidase Fluorescence Probe with Improved Cellular Accumulation Based on a Spirocyclized Rhodol Scaffold" Mako Kamiya, Daisuke Asanuma, Erina Kuranaga, Asuka Takeishi, Masayo Sakabe, Masayuki Miura, Tetsuo Nagano and Yasuteru Urano
J. Am. Chem. Soc.,
133, 12960-12963 (2011) doi:10.1021/ja204781t - "Rational Design of Boron Dipyrromethene (BODIPY)-based Photobleaching-resistant Fluorophore Applicable to Protein Dynamics Study" Toru Komatsu, Daihi Oushiki, Aoi Takeda, Masaki Miyamura, Tasuku Ueno , Takuya Terai, Kenjiro Hanaoka, Yasuteru Urano,Tomoko Mineno and Tetsuo Nagano
Chem. Comm.,
47, 10055-10057 (2011) doi:10.1039/C1CC13367E - "Fluorescent Probes for Sensing and Imaging" Tasuku Ueno and Tetsuo Nagano
Nat. Methods,
8, 642-645 (2011) doi:10.1038/nmeth.1663 - "Fluorescence Probe for Lysophospholipase C/NPP6 Activity and a Potent NPP6 Inhibitor" Mitsuyasu Kawaguchi, Takayoshi Okabe, Shinichi, Okudaira, Kenjiro Hanaoka, Yuuta Fujikawa, Takuya Terai, Toru Komatsu, Hirotatsu Kojima, Junken Aoki and Tetsuo Nagano
J. Am. Chem. Soc.,
133, 12021-12030 (2011) doi:10.1021/ja201028t - "Development of a Highly Sensitive Fluorescence Probe for Hydrogen Peroxide" Masahiro Abo, Yasuteru Urano, Kenjiro Hanaoka, Takuya Terai, Toru Komatsu and Tetsuo Nagano
J. Am. Chem. Soc.,
133, 10629-10637 (2011) doi:10.1021/ja203521e - "Development of an Si-rhodamine-based Far-red to Near-infrared Fluorescence Probe Selective for Hypochlorous Acid and Applications for Biological Imaging" Yuichiro Koide, Yasuteru Urano, Kenjiro Hanaoka, Takuya Terai and Tetsuo Nagano
J. Am. Chem. Soc.,
133, 5680-5682(2011) doi:10.1021/ja111470n - "Real-time measurements of protein dynamics using fluorescence activation-coupled protein labeling (FAPL) method" Toru Komatsu, Kai Johnsson, Hiroyuki Okuno, Haruhiko Bito, Takanari Inoue, Tetsuo Nagano and Yasuteru Urano
J. Am. Chem. Soc.,
133, 6745-6751 (2011) doi:10.1021/ja200225m - "Development of a Highly Selective Fluorescence Probe for Alkaline Phosphatase" Mitsuyasu Kawaguchi, Kenjiro Hanaoka, Toru Komatsu, Takuya Terai and Tetsuo Nagano
Bioorg. Med. Chem. Lett.,
21, 5088-5091 (2011) doi:10.1016/j.bmcl.2011.03.070 - "Evolution of Group 14 Rhodamines as Platforms for Near-infrared Fluorescence Probes Utilizing Photoinduced Electron Transfer" Yuichiro Koide, Yasuteru Urano, Kenjiro Hanaoka, Takuya Terai and Tetsuo Nagano
ACS Chem. Biol.,
6, 600-608 (2011) doi:10.1021/cb1002416 - "In Situ Evaluation of Kinetic Resolution Catalysts for Nitroaldol by using a Rationally Designed Fluorescence Probe" Takuya Matsumoto, Yasuteru Urano, Yoshinori Takahashi, Yusuke Mori, Takuya Terai and Tetsuo Nagano
J. Org. Chem.,
76, 3616-3625 (2011) doi:10.1021/jo1020344 - "Development of Fluorescein Analogue, TokyoMagenta, as a Novel Scaffold for Fluorescence Probes in Red Region" Takahiro Egawa, Yuichiro Koide, Kenjiro Hanaoka, Toru Komatsu, Takuya Terai and Tetsuo Nagano
Chem. Commum.,
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