研究業績 Publications

2010年

  • "Hypoxia-sensitive Fluorescent Probes for in vivo Real-time Fluorescence Imaging of Acute Ischemia" Kazuki Kiyose, Kenjiro Hanaoka, Daihi Oushiki, Tomomi Nakamura, Mayumi Kajimura, Makoto Suematsu, Hiroaki Nishimatsu, Takehiro Yamane, Takuya Terai, Yasunobu Hirata and Tetsuo Nagano, J. Am. Chem. Soc., 132, 15846-15848 (2010).
  • "A Time-Resolved Fluorescence Probe for Dipeptidyl Peptidase 4 and its Application for Inhibitor Screening" Mitsuyasu Kawaguchi, Takayoshi Okabe, Takuya Terai, Kenjiro Hanaoka, Hirotatsu Kojima, Izumi Minegishi and Tetsuo Nagano, Chemistry-A European Journal, 16, 13479-13486 (2010).
  • "Development of Fluorescent Probes for Bioimaging Applications" Tetsuo Nagano, The Proceedings of the Japan Academy, Series B, 86, .837-847 (2010) .
  • "Development of Enzyme-activated Photosensitizer Based on Intramolecular Electron Transfer" Takatoshi Yogo, Yasuteru Urano, Mako Kamiya, Kiminari Sano and Tetsuo Nagano, Bioorg. Med. Chem. Lett., 20, 4320-4323 (2010).
  • "Development of Luciferin Analogues Bearing an Amino Group and Their Application as BRET Donors" Hideo Takakura, Kiyoshi Sasakura, Tasuku Ueno, Yasuteru Urano, Takuya Terai, Kenjiro Hanaoka, Takashi Tsuboi and Tetsuo Nagano, Chemistry-An Asian Journal, 5, 2053-2061 (2010).
  • "A Fluorescence Correlation Spectroscopy-based Assay for Fragment Screening of Slowly Inhibiting Protein-peptide Interactions" Junko Mikuni, Miki Kato, Shigenao Taruya, Keiko Tsuganezawa, Masumi Mori, Naoko Ogawa, Teruki Honma, Shigeyuki Yokoyama, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano and Akiko Tanaka, Analytical Biochemistrey, 402, 26-31 (2010).
  • "Sensitive Detection of Acrolein in Serum Using Time-resolved Luminescence" Masataka Togashi, Yasuteru Urano, Hirotatsu Kojima, Takuya Terai, Kejiro Hanaoka, Kazuei Igarashi, Yasunobu Hirata and Tetsuo Nagano, Organic Letters, 12, 1704-1707 (2010).
  • "Establishment of an indicator cell system for hepatitis C virus" Yoshinori Tanaka, Yoshio Mori, Hideki Tani, Takayuki Abe, Kohji Moriishi, Hirotatsu Kojima, Tetsuo Nagano, Takayoshi Okabe, Tetsuro Suzuki, Masashi Tatsumi and Yoshiharu Matsuura, Microbiology and Immunology., 54, 206-220 (2010).
  • "Adipose Tissue-Derived Stem Cells Inhibit Neointimal Formation in a Paracrine Fashion in Rat Femoral Artery" Masao Takahashi, Etsu Suzuki, Shigeyoshi Oba, Hiroaki Nishimatsu, Kenjiro Kimura, Tetsuo Nagano, Ryozo Nagai and Yasunobu Hirata, Am. J. Physiol. Heart. Circ. Physiol., 298, H415-H423 (2010).
  • "Development and Application of a Near-infrared Fluorescence Probe for Oxidative Stress Based on Differential Reactivity of Linked Cyanine Dyes" Daihi Oushiki, Hirotatsu Kojima, Takuya Terai, Makoto Arita, Kenjiro Hanaoka, Yasuteru Urano and Tetsuo Nagano, J. Am. Chem. Soc., 132, 2795-2801 (2010).
  • "Design and Synthesis of a Highly Sensitive Off-On Fluorescent Chemosensor for Zinc Ion Utilizing Internal Charge Transfer" Kenjiro Hanaoka, Yasuaki Muramatsu, Yasuteru Urano, Takuya Terai and Tetsuo Nagano, Chemistry - A European Journal, 16, 568-572 (2010).
  • "大学における創薬研究　－スクリーニング－" 長野哲雄,岡部隆義, 『創薬科学の魅力』廣川書店, (2010)
  • "大学における創薬研究　－化合物ライブラリー－" 長野哲雄,小島宏建, 『創薬科学の魅力』廣川書店, (2010)
  • "創薬研究基盤としての化合物ライブラリーの構築" 小島宏建, 岡部隆義, 長野哲雄, 化学工業, 62, 36-42 (2010)

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2009年

  • "Development of 2,6-Carboxy-Substituted Boron Dipyrromethene (BODIPY) as a Novel Scaffold of Ratiometric Fluorescent Probes for Live Cell Imaging" Toru Komatsu, Yasuteru Urano, Yuuta Fujikawa, Tomonori Kobayashi, Hirotatsu Kojima, Takuya Terai, Kenjiro Hanaoka and Tetsuo Nagano, Chem. Comm., 7015-7017 (2009).
  • "Bioimaging Probes for Reactive Oxygen Species and Reactive Nitrogen Species" Tetsuo Nagano, J. Clin. Biochem. Nutr., 45, 111-124 (2009).
  • "Squalene as a Target Molecule in Skin Hyperpigmentation Caused by Singlet Oxygen" Akemi Ryu, Kumi Arakane, Chiharu Koide, Hiroyuki Arai , Biol. Pharm. Bull. , 32, 1504-1509 (2009).
  • Fluorescence Imaging of Tumors with “Smart” pH-Activatable Targeted Probes" Daisuke Asanuma, Hisataka Kobayashi, Tetsuo Nagano and Yasuteru Urano, Bioluminescence Methods in Molecular Biology , 574, 47-62 (2009).
  • "A Simple and Effective Strategy to Increase the Sensitivity of Fluorescence Probes in Living Cells" Saki Izumi, Yasuteru Urano, Kenjiro Hanaoka, Takuya Terai and Tetsuo Nagano, J. Am. Chem. Soc., 131, 10189-10200 (2009).
  • "Molecular Design Strategies for Near-infrared Ratiometric Fluorescent Probes Based on Unique Spectral Properties of Aminocyanines" Kazuki Kiyose, Sakiko Aizawa, Eita Sasaki, Hirotatsu Kojima, Yasuteru Urano, Kejiro Hanaoka, Takuya Terai and Tetsuo Nagano, Chemistry - A European Journal, 15, 9191-9200 (2009).
  • "Anion Sensor-Based Ratiometric Peptide Probe for Protein Kinase Activity" Kazuya Kikuchi, Shigeki Hashimoto, Shin Mizukami and Tetsuo Nagano, Organic Lett., 11, 2732-2735 (2009).
  • "A New Constitutively Acrive Mutant of AMP-activated Protein Kinase Inhibits Anoxia-induced Apoptosis of Vascular Endothelial Cell" DaisukeNagata, Arihiro Kiyosue, Masao Takahashi, Hiroshi Satonaka, Kimie Tanaka, Masataka Sata, Tetsuo Nagano, Ryozo Nagai and Yasunobu Hirata, Hypertension Research, 32, 133-139 (2009).
  • "Design and Development of Enzymatically Activatable Photosensitizer Based on Unique Characteristics of Thiazole Orange" Yuichiro Koide, Yasuteru Urano, Akira Yatsushige, Kenjiro Hanaoka, Takuya Terai and Tetsuo Nagano, J. Am. Chem. Soc., 131, 6058-6059 (2009).
  • "Use of Stable Isotope Ratios for Profiling of Industrial Ephedrine Samples: Application of Hydrogen Isotope Ratios in Combination with Carbon and Nitrogen" Naoki Kurashima, Yukiko Makino, Yasuteru Urano,Kaori Sanuki, Yukari Ikehara and Tetsuo Nagano, Forensic Science International , 189, 14-18 (2009).
  • "Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes" Yasuteru Urano, Daisuke Asanuma, Yukihiro Hama, Yoshinori Koyama, Tristan Barrett, Mako Kamiya, Tetsuo Nagano, Toshiaki Watanabe, Akira Hasegawa, Peter L. Choyke and Hisataka Kobayashi, Nature Medicine, 15, 104-109 (2009).
  • "創薬をめざした構造生物学とケミカルバイオロジーの融合研究"　長野哲雄、「PNE 蛋白質核酸酵素」共立出版、54、1439-1440（2009）.
  • "新しいがん細胞in vivoイメージング法の開発"　浅沼大祐、小林久隆、長野哲雄、浦野泰照、 Cancer Frontier「分子標的時代における分子診断、イメージング、遺伝子検査」医薬ジャーナル社、Vol.11、印刷中.
  • "MRI用センサー分子の分子設計・化学合成"　長野哲雄、花岡健二郎、化学フロンティア：新しい地平をひらく分析手法の最前線、化学同人、69-76 (2009)
  • "分子標的蛍光プロ－ブを利用したがんの特異的なイメージング法"　浅沼大祐、小林久隆、長野哲雄、浦野泰照、『がん分子標的治療研究マニュアル』日本がん分子標的治療学会編、印刷中
  • "分子の蛍光性制御と蛍光プローブ開発1, 2 & 3"　上野　匡、長野哲雄、「薬学分析科学の最前線」日本薬学会物理系薬学部会分析化学担当教員会議編、（株）じほう、162-167 (2009).

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2008年

  • "Fluorescent Probes for Bioimaging Applications" Takuya Terai and Tetsuo Nagano, Current Opinion in Chemical Biology, 12,515-521 (2008).
  • "Design and Synthesis of Highly Sensitive Fluorogenic Substrates for Glutathione S-transferase (GST) and Application for Activity Imaging in Living Cells" Yuuta Fujikawa, Yasuteru Urano, Toru Komatsu, Kenjiro Hanaoka, Hirotatsu Kojima, Takuya Terai, Hideshi Inoue and Tetsuo Nagano, J. Am. Chem. Soc.,130, 14533-14543 (2008).
  • "Blockade of Endogenous Proinflammatory Cytokines Ameliorates Endothelial Dysfunction in Obese Zucker Rats" Nishimatsu H, Suzuki E, Takeda R, Takahashi M, Oba S, Kimura K, Nagano T and Hirata Y, Hypertens. Res., 31, 737-743 (2008).
  • "Calcineurin is Critical for Sodium-Induced Neointimal Formation in Normotensive And Hypertensive Rats" Takeda R, Suzuki E, Takahashi M, Oba S, Nishimatsu H, Kimura K, Nagano T, Nagai R and Hirata Y., Am. J.Physiol. Heart Circ. Physiol., 294, H2871-H2878 (2008).
  • "Angiotensin II and Tumor Necrosis Factor-α Synergistically Promote Monocyte Chemoattractant Protein-1 Expression: Roles of NF-κB, p38 and Reactive Oxygen Species" Takahashi M, Suzuki E, Takeda R, Oba S, Nishimatsu H, Kimura K, Nagano T, Nagai R and Hirata Y., Am. J. Physiol. Heart Circ. Physiol., 294, H2879-H2888 (2008).
  • "Development of a Novel Fluorescent Probe for Fluorescence Correlation Spectroscopic Detection of Kinase Inhibitors" Mitsuyasu Kawaguchi, Takuya Terai, Rei Utata, Miki Kato, Keiko Tsuganezawa, Akiko Tanaka, Hirotatsu Kojima, Takayosi Okabe and Tetsuo Nagano, Bioorganic & Medicinal Chemistry Letters, 18, 3752-3755 (2008).
  • "The detection limit of a Gd3+ -based T1 agent is substantially reduced when targeted to a protein microdomain" Kenjiro Hanaoka, Angelo Josue M. Lubag, Aminta Castillo-Muzquiz, Thomas Kodadek, A. Dean Sherry, Magnetic Resonance Imaging, 26, 608-617 (2008).
  • "Selective Photoinactivation of Protein Function through Environment-sensitive Switching of Singlet Oxygen Generation by Photosensitizer" Takatoshi Yogo, Yasuteru Urano, Akiko Mizushima, Hisato Sunahara, Takanari Inoue, Kenzo Hirose, Masamitsu Iino, Kazuya Kikuchi and Tetsuo Nagano, Proc. Natl. Acad. Sci., 105, 28-32 (2008).
  • "Evaluation of Characteristic Deuterium Distributions of Ephedrines and Methamphetamines by NMR Spectroscopy for Drug Profiling” Teruki Matsumoto, Yasuteru Urano, Yukiko Makino, Ruri Kikura-Hanajiri, Nobuo Kawahara, Yukihiro Goda and Tetsuo Nagano, Analytical Chemistry, 80, 1176-1181 (2008).
  • "A Gd3+-Based Magnetic Resonance Imaging Contrast Agent Sensitive to beta-Galactosidase Activity Utilizing a Receptor-Induced Magnetization Enhancement (RIME) Phenomenon" Kenjiro Hanaoka, Kazuya Kikuchi, Takuya Terai, Toru Komatsu and Tetsuo Nagano, Chemistry - A European Journal, 14, 987-995 （2008）.
  • "Functional Near-Infrared Fluorescent Probes" Kazuki Kiyose, Hirotatsu Kojima and Tetsuo Nagano, Chemistry-An Asian Journal, 3, 506-515 (2008).
  • "化合物ライブラリー"　長野哲雄、岡部隆義、小島宏建、Medical Science Digest, 34, 432-433 (2008).
  • "大学における創薬研究に必要な基盤は何か　－大学でなぜ薬が作れないのか－"　長野哲雄、現代化学、５月号 (2008).
  • "MRI用センサー分子の分子設計・化学合成"　長野哲雄、花岡健二郎、化学フロンティア：切り拓き、サイエンスを牽引する分析最前線 化学同人、 印刷中.
  • "ケミカルバイオロジー研究"　東京大学創立130周年記念出版物「アカデミック・グルーブ」、東京大学出版会、30-31 (2008)
  • "光イメージングとイメージングプローブ"　分子イメージング学会、Vol. 1(No. 1) (2008)
  • "巻頭言：日本におけるケミカルバイオロジー研究を考える"　日本ケミカルバイオロジー研究会会員誌、Vol. 1(No. 1) (2008)
  • "分子プローブによる細胞イメージング"　小島宏建、長野哲雄、日本薬理学雑誌、132、7-10 (2008)

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2007年

  • "Site-Specific Oxidative Stress Induction" Takuya Terai and Tetsuo Nagano, Chemistry & Biology (Previews), 14, 877-878 (2007).
  • "Time-Resolved Long-Lived Luminescence Imaging Method Employing Luminescent Lanthanide Probes with a New Microscopy System" Kenjiro Hanaoka, Kazuya Kikuchi, Shigeru Kobayashi and Tetsuo Nagano, J. Am. Chem. Soc., 129, 13502-13509 (2007).
  • "Iron Hydroxide Nanoparticles Coated With Poly(ethylene glycol)-poly(aspartic acid) Block Copolymer As Novel Magnetic Resonance Contrast Agents For In Vivo Cancer Imaging" ,Michiaki Kumagai, Yutaka Imai, Teisaku Nakamura, Yuichi Yamasaki, Masaki Sekino, Shoogo Ueno, Kenjiro Hanaoka, Kazuya Kikuchi, Tetsuo Nagano, Eiji Kaneko, Kentaro Shimokado and Kazunori Kataoka, Colloids and Surfaces B: Biointerfaces, 56, 174-181 (2007).
  • "Design and Synthesis of Fluorescent Probes for Selective Detection of Highly Reactive Oxygen Species in Mitochondria of Living Cells" Yuichiro Koide, Yasuteru Urano, Suguru Kenmoku, Hirotatsu Kojima and Tetsuo Nagano, J. Am. Chem. Soc., 129, 10324-10325 (2007).
  • "Development of an Iminocoumarin-Based Zinc Sensor Suitable for Ratiometric Fluorescence Imaging of Neuronal Zinc" Kensuke Komatsu,Yasuteru Urano, Hirotatsu Kojima and Tetsuo Nagano, J. Am. Chem. Soc., 129, 13447-13454 (2007).
  • "A Thiol-Reactive Fluorescence Probe Based on Donor-Excited Photoinduced Electron Transfer: Key Role of Ortho Substituion" Takuya Matsumoto, Yasuteru Urano, Takuji Shoda, Hirotatsu Kojima and Tetsuo Nagano, Org. Lett., 9, 3375-3377 (2007).
  • "Highly Activatable and Rapidly Releasable Caged Fluorescein Derivatives" Tomonori Kobayashi, Yasuteru Urano, Mako Kamiya, Tasuku Ueno, Hirotatsu Kojima and Tetsuo Nagano, J. Am. Chem. Soc.,129, 6696-6697 (2007).
  • “Development of a Highly Specific, Rhodamine-Based Fluorescence Probe for Hypochlorous Acid and Its Application to Real-Time Imaging of Phagocytosis” Suguru Kenmoku, Yasuteru Urano, Hirotatsu Kojima and Tetsuo Nagano, J. Am. Chem. Soc., 129, 7313-7318 (2007).
  • "Design and Synthesis of a Library of BODIPY-Based Environmental Polarity Sensors Utilizing Photoinduced Electron Transfer-Controlled Fluorescence ON/OFF Switching" Hisato Sunahara, Yasuteru Urano, Hirotatsu Kojima, and Tetsuo Nagano, J. Am. Chem. Soc., 129, 5597-5604 (2007).
  • "An Enzymatically Activated Fluorescence Probe for Targeted Tumor Imaging" Mako Kamiya, Hisataka Kobayashi, Yukihiro Hama, Yoshinori Koyama, Marcelino Bernardo, Tetsuo Nagano, Peter L. Choyke and Yasuteru Urano, J. Am. Chem. Soc., 129，3918-3929 (2007).
  • "一酸化窒素（NO）プローブ群の開発"　小島宏建、長野哲雄、PNE 蛋白質　核酸　酵素、52，1534-1539（2007）.
  • "ケミカルバイオロジー概論"　長野哲雄、PNE 蛋白質　核酸　酵素、52，1519-1523（2007）.
  • "蛍光標識法　～蛍光で生体分子を光らせる～"　上野　匡、浅沼大祐、長野哲雄、実験医学別冊実験ハンドブックシリーズ「生命科学のための機器分析実験ハンドブック」（西村善文編集）、pp. 27-34 (2007).
  • "意義と将来的展望"　長野哲雄、別冊化学　「分子イメージング」、14-16（2007）.
  • "酸化ストレスマーカーの測定、蛍光法"　長野哲雄、日本医学出版、「酸化ストレス と心血管病」89-94 (2007).
  • "分子イメージングプローブの開発"　上野　匡、浦野泰照、長野哲雄、日本臨床、65，247-252（2007）.
  • "マクマリー生化学反応機構―ケミカルバイオロジーの理解のために―" 長野哲雄　監訳、浦野　泰照、小島　宏建、鈴木　紀行、平野　智也訳、東京化学同人 (2007).

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2006年

  • "Fluorescence-based zinc ion sensor for zinc ion release from pancreatic cells" Crivat, G., Kikuchi, K., Nagano, T., Priel, T., Hershfinkel, M., Sekler, I., Rosenzweig, N., Rosenzweig, Z., Anal. Chem., 78，5799- 5804（2006）.
  • "Design and Synthesis of an Enzyme Activity-Based Labeling Molecule with Fluorescence Spectral Change" Toru Komatsu, Kazuya Kikuchi, Hideo Takakusa, Kenjiro Hanaoka, Tasuku Ueno, Mako Kamiya, Yasuteru Urano and Tetsuo Nagano, J. Am. Chem. Soc., 128，15946-15947（2006）.
  • "Creation of Superior Carboxyfluorescein Dyes by Blocking Donor-Excited Photoinduced Electron Transfer" Tomoko Mineno, Tasuku Ueno, Yasuteru Urano, Hirotatsu Kojima and Tetsuo Nagano, Org. Lett., 8，5963-5966（2006）.
  • "Mechanism-Based Molecular Design of Highly Selective Fluorescence Probes for　Nitrative Stress" Tasuku Ueno, Yasuteru Urano, Hirotatsu Kojima and Tetsuo Nagano. J. Am. Chem. Soc., 128, 10640-10641 (2006).
  • "Tunable Design Strategy for Fluorescence Probes Based on 4-Substituted BODIPY Chromophore; Improvement of Highly Sensitive Fluorescence Probe for Nitric Oxide" Yu Gabe, Tasuku Ueno, Yasuteru Urano, Hirotatsu Kojima and Tetsuo Nagano, Analytical and Bioanalytical Chemistry, 386，621-626（2006）.
  • "Development of a Ratiometric Fluorescent Zinc Ion Probe in Near-Infrared Region, Based on Tricarbocyanine Chromophore" Kazuki Kiyose, Hirotatsu Kojima, Yasuteru Urano and Tetsuo Nagano, J. Am. Chem. Soc., 128, 6548-6549 (2006).
  • "Inhibition of Presynaptic Activity by Zinc Released from Mossy Terminals during Tetanic Stimulation" Akira Minami, Naomi Sakurada, Sayuri Fuke, Kazuya Kikuchi,, Tetsuo Nagano, Naoto Oku, and Atsushi Takeda, Journal of Neuroscience Research, 83, 167-176 (2006).
  • "Modulation of Luminescence Intensity of Lanthanide Complexes by Photoinduced Electron Transfer and Its Application to a Long-Lived Protease Probe" Takuya Terai, Kazuya Kikuchi, Shin-ya Iwasawa, Takao Kawabe, Yasunobu Hirata, Yasuteru Urano and Tetsuo Nagano, J. Am. Chem. Soc., 128, 6938-6946 (2006).
  • "教育制度への期待と夢" 長野哲雄、小林　進、林　正弘、山岡由美子、辻　勉, ファ ルマシア, 42, 201-206 (2006).
  • "世界初のケミカルバイオロジー研究会年会"　細胞工学、25, 1050-1052 (2006).
  • "鼎談　日本で誕生！世界初のケミカルバイオロジー研究会"　長野哲雄、萩原正敏、 長田裕之、Bionics、23 (10)、 52-55 (2006).
  • "蛍光プローブを用いる分子イメージング"　浦野泰照、化学、61、20-22　（2006）
  • "分子イメージングは化学者が主役になれる新しい分野"　長野哲雄、化学、61、12-15　（2006）
  • "蛍光プローブ　－ランタノイド金属の蛍光を用いた高感度臨床診断薬の開発－"　長野哲雄、寺井琢也、脈管学、46、743-748　（2006）.
  • "バイオイメージングプローブの開発と生体への応用に関する研究"　長野哲雄、薬学雑誌、126、901-913　（2006）
  • "薬学研究の将来像"　長野哲雄、ファルマシア、42、775　（2006）
  • "分子イメージングと蛍光プローブ"　長野哲雄、バイオサイエンスとインダストリー、64, 201-207 (2006)
  • "ケミカルバイオロジーの概念"　長野哲雄、現代化学、2006年4月号、16-20

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