研究業績 Publications

2012年

  • "Reversible Off-On Fluorescence Probe for Hypoxia and Imaging of Hypoxia-Normoxia Cycles in Live Cells" Shodai Takahashi, Wen Piao, Yuriko Matsumura, Toru Komatsu, Tasuku Ueno, Takuya Terai, Toshiaki Kamachi, Masahiro Kohno, Tetsuo Nagano and Kenjiro Hanaoka, J. Am. Chem. Soc., 134, 19588-19591 (2012).
  • "Flexibility of the P-loop of Pim-1 Kinase: Observation of a Novel Conformation Induced by Interaction with an Inhibitor" Lorien J. Parker, Hisami Watanabe, Keiko Tsuganezawa, Yuri Tomabechi, Noriko Handa, Mikako Shirouzu, Hitomi Yuri, Teruki Honma, Naoko Ogawa, Tetsuo Nagano, Shigeyuki Yokoyama and Akiko Tanaka, Acta Cryst., Sec. F Struct. Biol. Cryst. Commun., 68, 860-866 (2012).
  • "Structural Basis for Specific Recognition of Substrates by Sapovirus Protease" Masaru Yokoyama, Tomoichiro Oka, Hirotatsu Kojima, Tetsuo Nagano, Takayoshi Okabe, Kazuhiko Katayama, Takaji Wakita, Tadahito Kanda and Hironori Sato, Frontiers in Virology, 3, Article312 (2012).
  • "Design Strategy for a Near-infrared (NIR) Fluorescence Probe for Matrix Metalloproteinase Utilizing Highly Cell-permeable Boron Dipyrromethene (BODIPY)" Takuya Myochin, Kenjiro Hanaoka, Toru Komatsu, Takuya Terai and Tetsuo Nagano, J. Am. Chem. Soc., 134, 13730-13737 (2012).
  • "Highly Activatable and Environment-insensitive Optical Highlighters for Selective Spatiotemporal Imaging of Target Proteins" Tomonori Kobayashi, Toru Komatsu, Mako Kamiya, Cláudia Campos, Marcos González-Gaitán, Takuya Terai, Kenjiro Hanaoka, Tetsuo Nagano and Yasuteru Urano, J. Am. Chem. Soc., 134, 11153-11160 (2012).
  • "Fluorescence Endoscopic Detection of Murine Colitis-Associated Colon Cancer by Topically Applied Enzymatically Rapid-Activatable Probe" Makoto Mitsunaga, Nobuyuki Kosaka, Peter Choyke, Matthew Young, Christopher R Dextras, Shakir M Saud,Nancy H. Colburn, Masayo Sakabe, Tetsuo Nagano, Daisuke Asanuma, Yasuteru Urano and Hisataka Kobayashi, Gut, in press.
  • "Identification of Novel Drug-Resistant EGFR Mutant Inhibitors by in silico Screening Using Comprehensive Assessments of Protein Structures" Tomohiro Sato, Hisami Watanabe, Keiko Tsuganezawa, Hitomi Yuki, Junko Mikuni, Seiko Yoshikawa, Mutsuko Kukimoto-Niino, Takako Fujimoto, Yumiko Terazawa, Motoaki Wakiyama, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Mikako Shirouzu, Shigeyuki Yokoyama, Akiko Tanaka and Teruki Honma, Bioorg. Med. Chem., 20, 3756-3767 (2012).
  • "Rational Evolution of a Novel Type of Potent and Selective Proviral Integration Site in Moloney Murine Leukemia Kinase 1 (PIM1) Inhibitor from a Screening-hit Compound" Hirofumi Nakano, Nae Saito, Lorien Parker, Yukio Tada, Masanao Abe, Keiko Tsuganezawa, Shigeyuki Yokoyama, Akiko Tanaka, Hirotatsu Kojima, Takayoshi Okabe and Tetsuo Nagano, J. Med. Chem., 55, 5151-5164 (2012).
  • "Red Fluorescent Scaffold for Highly Sensitive Protease Activity Probes" Yu Kushida, Kenjiro Hanaoka, Toru Komatsu, Takuya Terai, Tasuku Ueno, Kengo Yoshida, Masanobu Uchiyama, Tetsuo Nagano, Bioorg. Med. Chem. Lett., 22, 3908-3911(2012).
  • "Development of 5’- and 7’-Substituted Luciferin Analogues as Acid-Tolerant Substrates of Firefly Luciferase" Hideo Takakura, Ryosuke Kojima, Takeaki Ozawa, Tetsuo Nagano and Yasuteru Urano, ChemBiolChem, 13, 1-4(2012).
  • "Near-infrared Fluorescence Probes for Enzymes Based on Binding Affinity Modulation of Squarylium Dye Scaffold" Daihi Oushiki, Hirotatsu Kojima, Yuki Takahashi, Toru Komatsu, Takuya Terai, Kenjiro Hanaoka, Makiya Nishikawa, Yoshinobu Takakura and Tetsuo Nagano, Anal. Chem., 84, 4404-4410 (2012).
  • "Salicyclic Acid Derivatives as Antennae for Ratiometric Luminescent Probes Based on Lanthanide Complexes" Takuya Terai, Hiroki Ito, Kazuya Kikuchi, and Tetsuo Nagano, Chemistry-A European Journal, 13, 7377-7381(2012).
  • "Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells" Robert DeRose, Christopher Pohlmeyer, Nobuhiro Umeda, Tasuku Ueno, Tetsuo Nagano, Scot Kuo, and Takanari Inoue, Journal of Visualized Experiments, 61, e3794(2012).
  • "Blockade of Inflammatory Responses by a Small-Molecule Inhibitor of the Rac Activator DOCK2" Akihiko Nishikimi, Takehito Uruno, Xuefeng Duan, Qinhong Cao, Yuji Okamura, Takashi Saitoh, Nae Saitoh, Shunsuke Sakaoka, Yao Du, Atsushi Suenaga, Mutsuko Kukimoto-Niino, Kei Miyano, Kazuhito Gotoh, Takayoshi Okabe, Fumiyuki Sanematsu, Yoshihiko Tanaka, Hideki Sumimoto, Teruki Honma, Shigeyuki Yokoyama, Tetsuo Nagano, Daisuke Kohda, Motomu Kanai and Yoshinori Fukui, Chem. & Biol., 19, 488-497 (2012).
  • "Development of NIR Fluorescent Dyes Based on Si-Rhodamine for In Vivo Imaging" Yuichiro Koide, Yasuteru Urano, Kenjiro Hanaoka, Wen Piao, Moriaki Kusakabe, Nae Saito, Takuya Terai, Takayoshi Okabe and Tetsuo Nagano, J. Am. Chem. Soc., 134, 5029-5031 (2012).
  • "Development of of hypoxia-sensitive Gd3+-based MRI contrast agents" Shimpei Iwaki, Kenjiro Hanaoka, Wen Piao, Toru Komatsu, Tasuku Ueno, Takuya Terai and Tetsuo Nagano, Bioorg. Med. Chem. Lett., 22, 2798-2802 (2012).
  • "A Reversible Near-Infrared Fluorescence Probe for Reactive Oxygen Species Based on Te-rhodamine" Yuichiro Koide, Mitsuyasu Kawaguchi, Yasuteru Urano, Kenjiro Hanaoka, Toru Komatsu, Takuya Terai and Tetsuo Nagano, Chem. Commun., 48, 3091-3093 (2012).
  • "Visible-Light-Triggered Release of Nitric Oxide from N-Pyramidal Nitrosamines" Fumika Karaki, Yoji Kabasawa, Takahiro Yanagimoto, Nobuhiro Umeda,Yasuteru Urano, Tetsuo Nagano, Yuki Otani and Tomohiko Ohwada, Chemistry-A European Journal, 18, 1127-1141(2012).
  • "A Long-Lived Luminescent Probe to Sensitively Detect Arylamine N-Acetyltransferase (NAT) Activity of Cells" Takuya Terai, Kazuya Kikuchi, Yasuteru Urano, Hirotatsu Kojima and Tetsuo Nagano, Chem. Commun., 48, 2234-2236(2012).
  • "A Practical Strategy to Create Near-Infrared Luminescent Probes: Conversion from Fluorescein-Based Sensors" Takuya Terai, Yasuteru Urano, Saki Izumi, Hirotatsu Kojima and Tetsuo Nagano, Chem. Commun., 48, 2840-2842(2012).
  • "A Novel Pim-1 Kinase Inhibitor Targeting Residues that Bind the Substrate Peptide" Keiko Tsuganezawa, Hisami Watanabe, Lorien Parker, Hitomi Yuki, Shigenao Taruya, Yukari Nakagawa, Daisuke Kamei, Masami Mori, Naoko Ogawa, Yuri Tomabechi, Noriko Handa, Teruki Honma, Shigeyuki Yokoyama, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano and Akiko Tanaka, J. Mol. Biol., 417, 240-252 (2012).
  • "アカデミア創薬の幕開け　－大学で取り組む本格的創薬研究－" 長野哲雄、岡部隆義、小島宏建, 現代化学、11月号,pp26-30 (2012)
  • "ケミカルバイオロジー" 花岡健二郎、長野哲雄, 化学便覧応用化学編、丸善, 印刷中
  • "公的大規模化合物ライブラリーを基盤とする創薬オープンイノベーション" 小島宏建、岡部隆義、長野哲雄, 日本臨牀, 70巻, 298-302 (2012)
  • "機能性MRI造影剤の分子設計および動脈硬化イメージング" 花岡健二郎, 『疾患克服を目指したケミカルバイオロジー』、実験医学(増刊号), 30, 1120-1127 (2012)
  • "誰もが使える化合物ライブラリーの構築によるスクリーニングから始める創薬研究の促進" 小島宏建、岡部隆義、長野哲雄, 『疾患克服を目指した革新的最新技術』、実験医学(増刊号), 30, 1234-1239 (2012).
  • "3章　バイオセンシングの歴史と将来展望" 花岡健二郎、長野哲雄, 『CSJカレントレビュー第10巻　ここまで進んだバイオセンシング・イメージング』 化学同人、日本化学会編, pp15-19 (2012).
  • "創薬研究への応用を目指した蛍光プローブの開発" 寺井琢也、長野哲雄, 化学工業, 63, 47-53 (2012)

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2011年

  • "Rapid Cancer Detection by Topically Spraying a Gamma-glutamyltranspeptidase-activated Fluorescent Probe" Yasuteru Urano, Masayo Sakabe, Nobuyuki Kosaka, Mikako Ogawa, Makoto Mitsunaga, Daisuke Asanuma, Mako Kamiya, Matthew R.Young, Tetsuo Nagano, Peter L. Choyke, Hisataka Kobayashi, Science Translational Medicine, 3, 110-119 (2011).
  • "Activatable Optical Imaging with a Silica-Rhodamine Based Near Infrared (SiR700) Fluorophore: A comparison with cyanine based dyes" Thomas E. McCann, Nobuyuki Kosaka, Yuichiro Koide, Makoto Mitsunaga, Peter L. Choyke, Tetsuo Nagano, Yasuteru Urano and Hisataka Kobayashi, Bioconjugate Chemistry, 22, 2531-2538 (2011).
  • "Development of a Highly Selective Fluorescence Probe for Hydrogen Sulfide" Kiyoshi Sasakura, Kenjiro Hanaoka, Norihiro Shibuya, Yoshinori Mikami, Yuka Kimura, Toru Komatsu, Tasuku Ueno, Takuya Terai, Hideo Kimura, and Tetsuo Nagano, J. Am. Chem. Soc., 133, 18003-18005 (2011).
  • "Selective Two-Step Labeling of Proteins with an Off-On Fluorescence Probe" Kazuhisa Hirabayashi, Kenjiro Hanaoka, Manabu Shimonishi, Takuya Terai, Toru Komatsu, Tasuku Ueno and Tetsuo Nagano, Chemistry-A European Journal, 17, 14763-14771 (2011).
  • "Method for Enhancing Cell-penetration of Gd3+-based MRI Contrast Agents by Conjugation with Hydrophobic Fluorescent Dyes" Takehiro Yamane, Kenjiro Hanaoka, Yasuaki Muramatsu, Keita Tamura, Yusuke Adachi, Yasushi Miyashita, Yasunobu Hirata and Tetsuo Nagano, Bioconjugate Chemistry, 22, 2227-2236 (2011).
  • "Development of a Potassium Ion-Selective Fluorescent Sensor Based on 3-Styrylated BODIPY" Tomoya Hirata, Takuya Terai, Toru Komatsu, Kenjiro Hanaoka and Tetsuo Nagano, Bioorganic & Medicinal Chemistry Letters, 21, 6090-6093 (2011).
  • "Development of a Far-Red to Near-Infrared Fluorescence Probe for Calcium Ion and its Application to Multicolor Neuronal Imaging" Takahiro Egawa, Kenjiro Hanaoka, Yuichiro Koide, Sakiko Ujita, Naoya Takahashi, Yuji Ikegaya, Norio Matsuki, Takuya Terai, Tasuku Ueno, Toru Komatsu and Tetsuo Nagano, J. Am. Chem. Soc., 133, 14157-14159 (2011).
  • "Rational Development of Caged-Biotin Protein-Labeling Agents and Some Applications in Live Cells" Takuya Terai, Eri Maki, Shigeru Sugiyama, Yoshinori Takahashi, Hiroyoshi Matsumura, Yusuke Mori and Tetsuo Nagano, Chemistry & Biology, 18, 1261-1272 (2011).
  • "β-Galactosidase Fluorescence Probe with Improved Cellular Accumulation Based on Spirocyclized Rhodol Scaffold" Mako Kamiya, Daisuke Asanuma, Erina Kuranaga, Asuka Takeishi, Masayo Sakabe, Masayuki Miura, Tetsuo Nagano and Yasuteru Urano, J. Am. Chem. Soc., 133, 12960-12963 (2011).
  • "Rational Design of Boron Dipyrromethene (BODIPY)-based Photobleaching-resistant Fluorophore Applicable to Protein Dynamics Study" Toru Komatsu, Daihi Oushiki, Aoi Takeda, Masaki Miyamura, Tasuku Ueno , Takuya Terai, Kenjiro Hanaoka, Yasuteru Urano,Tomoko Mineno and Tetsuo Nagano, Chem. Comm., 47, 10055-10057 (2011).
  • "Fluorescent Probes for Sensing and Imaging" Tasuku Ueno and Tetsuo Nagano, Nature Methods, 8, 642-645 (2011).
  • "Fluorescence Probe for Lysophospholipase C/NPP6 Activity and a Potent NPP6 Inhibitor" Mitsuyasu Kawaguchi, Takayoshi Okabe, Shinichi, Okudaira, Kenjiro Hanaoka, Yuuta Fujikawa, Takuya Terai, Toru Komatsu, Hirotatsu Kojima, Junken Aoki and Tetsuo Nagano, J. Am. Chem. Soc., 133, 12021-12030 (2011).
  • "Development of a Highly Sensitive Fluorescence Probe for Hydrogen Peroxide" Masahiro Abo, Yasuteru Urano, Kenjiro Hanaoka, Takuya Terai, Toru Komatsu and Tetsuo Nagano, J. Am. Chem. Soc., 133, 10629-10637 (2011).
  • "Virtual Screening and Further Development of Novel ALK Inhibitors" Masako Okamoto, Hirotatsu Kojima, Nae Saito, Takayoshi Okabe, Yoshiaki Masuda, Toshio Furuya and Tetsuo Nagano, Bioorganic & Medicinal Chemistry, 19, 3086-3095 (2011).
  • "Development of an Si-rhodamine-based Far-red to Near-infrared Fluorescence Probe Selective for Hypochlorous Acid and Applications for Biological Imaging" Yuichiro Koide, Yasuteru Urano, Kenjiro Hanaoka, Takuya Terai and Tetsuo Nagano, J. Am. Chem. Soc., 133, 5680-5682(2011).
  • "Real-time measurements of protein dynamics using fluorescence activation-coupled protein labeling (FAPL) method" Toru Komatsu, Kai Johnsson, Hiroyuki Okuno, Haruhiko Bito, Takanari Inoue, Tetsuo Nagano and Yasuteru Urano, J. Am. Chem. Soc., 133, 6745-6751 (2011).
  • "Development of a Highly Selective Fluorescence Probe for Alkaline Phosphatase" Mitsuyasu Kawaguchi, Kenjiro Hanaoka, Toru Komatsu, Takuya Terai and Tetsuo Nagano, Bioorganic & Medicinal Chemistry Letters, 21, 5088-5091 (2011).
  • "Evolution of Group 14 Rhodamines as Platforms for Near-infrared Fluorescence Probes Utilizing Photoinduced Electron Transfer" Yuichiro Koide, Yasuteru Urano, Kenjiro Hanaoka, Takuya Terai and Tetsuo Nagano, ACS Chemical Biology, 6, 600-608 (2011).
  • "A Dual Inhibitor against Prolyl Isomerase Pin1 and Cyclophilin Discovered by a Novel Real-time Fluorescence Detection Method" Tadashi Mori, Masafumi Hidaka, Yi-Chin Lin, Ibuki Yoshizawa, Takayoshi Okabe, Shinichiro Egashira, Hirotatsu Kojima, Tetsuo Nagano, Mamoru Koketsu, Mari Takamiya and Takafumi Uchida, Biochem. Biophys. Res. Comm.,406, 439-443 (2011).
  • "In Situ Evaluation of Kinetic Resolution Catalysts for Nitroaldol by using a Rationally Designed Fluorescence Probe" Takuya Matsumoto, Yasuteru Urano, Yoshinori Takahashi, Yusuke Mori, Takuya Terai and Tetsuo Nagano, J. Org. Chem., 76, 3616-3625 (2011).
  • "Development of Fluorescein Analogue, TokyoMagenta, as a Novel Scaffold for Fluorescence Probes in Red Region" Takahiro Egawa, Yuichiro Koide, Kenjiro Hanaoka, Toru Komatsu, Takuya Terai and Tetsuo Nagano, Chem. Comm., 47, 4162-4164 (2011).
  • "Rational Design of Ratiometric Near-Infrared Fluorescent pH Probes with Various pKa Values, Based on Aminocyanine" Takuya Myochin, Kazuki Kiyose, Kenjiro Hanaoka, Hirotatsu Kojima, Takuya Terai and Tetsuo Nagano, J. Am. Chem. Soc., 133, 3401-3409 (2011).
  • "Aminoluciferins as Functional Bioluminogenic Substrates of Firefly Luciferase" Hideo Takakura, Ryosuke Kojima, Yasuteru Urano, Takuya Terai, Kenjiro Hanaoka and Tetsuo Nagano, Chemistry-An Asian Journal, 6, 1800-1810 (2011).
  • "Phosphatidylinositol-4 kinase III beta is a target of enviroxime-like compounds for anti-poliovirus activity" Minetaro Arita, Hirotatsu Kojima, Tetsuo Nagano, Takayoshi Okabe, Takaji Wakita, and Hiroyuki Shimizu, J. Virol., 85, 2364-2372 (2011).
  • "A Photocleavable Rapamycin Conjugate for Spatiotemporal Control of Small GTPase Activity" Nobuhiro Umeda, Tasuku Ueno, Christopher Pohlmeyer, Tetsuo Nagano and Takanari Inoue, J. Am. Chem. Soc., 133, 12-14 (2011).
  • "Positive Correlation Between the Generation of Reactive Oxygen Species and Activation/Reactivation of Transgene Expression After Hydrodynamic Injections into Mice" Naomi Takiguchi, Yuki Takahashi, Makiya Nishikawa, Yuriko Matsui, Yasushi Fukuhara, Daihi Oushiki, Kazuki Kiyose, Kenjiro Hanaoka, Tetsuo Nagano and Yoshinobu Takakura, Pharm. Res., 28, 702-711 (2011).
  • "Identification of Novel ASK1 Inhibitors Using Virtual Screening" Masako Okamoto, Nae Saito, Hirotatsu Kojima, Takayoshi Okabe, Kohsuke Takeda, Hidenori Ichijo, Toshio Furuya and Tetsuo Nagano, Bioorganic & Medicinal Chemistry, 19, 486-489 (2011).
  • "Design and Synthesis of a Novel Fluorescence Probe for Zn2+ Based on the Spirolactam Ring-opening Process of Rhodamine Derivatives" Hiromi Sasaki, Kenjiro Hanaoka, Yasuteru Urano, Takuya Terai and Tetsuo Nagano, Bioorganic & Medicinal Chemistry, 19, 1072-1078 (2011).
  • "創薬研究基盤としての化合物ライブラリーの構築" 小島宏建、岡部隆義、長野哲雄, 化学工業, 62, 36-42 (2011)
  • "日本の創薬オープンイノベーションの幕開け" 長野哲雄, BIO Clinica, 26巻7月号, 13 (2011)
  • "有機蛍光プローブ" 寺井琢也, 長野哲雄, 『蛍光イメージング／MRIプローブの開発と最新動向』シーエムシー出版,(2011)
  • "MRI造影剤" 花岡健二郎, 長野哲雄, 『蛍光イメージング／MRIプローブの開発と最新動向』シーエムシー出版,(2011)
  • "ケミカルバイオロジーは何を目指すか" 長野哲雄, 化学と工業,64,030-033 (2011)

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